General Information
|
|
Product
|
IFI16 Peptide
|
Description
|
Antigenic Blocking Peptide Gamma-interferon-inducible protein 16 isoform 1
|
Verified Applications
|
Immunodepletion, Immunocompetition
|
Peptide Description
|
Synthetic peptide
|
Accession #
|
NCBI: NP_001193496.1
|
Physical Properties
|
|
Quantity
|
250 µg
|
Volume
|
100 µl
|
Form
|
Antigenic Blocking Peptide
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Competition/Depletion assay
|
Refer to competition assay protocol
|
Protein
|
Uniprot #
|
Q16666
|
Overview
|
Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein.
|
Molecular Function
|
Core promoter binding, identical protein binding, transcription factor binding, double-standard DNA binding, poly(A) RNA binding
|
Subcellular Location
|
Nucleus, cytoplasm (Note: Cellular distribution is dependent on acetylation status of multipartite nuclear localization signal(NLS); NLS acetylation promotes cytoplasmic localization. Localizes in nucleus during human herbes simplex virus 1 infection)
|
Expression
|
Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prosta
|
Alternative Nomenclature
|
IFI16 antibody
Gamma interferon inducible protein 16 antibody
Ifi204 antibody
IFNGIP1 antibody
interferon activated gene 204 antibody
Interferon gamma inducible protein 16 antibody
p204 antibody
PYHIN2 antibody
|
|
|