General Information
|
|
Product
|
MAPK3 Peptide
|
Description
|
Antigenic Blocking Peptide Mitogen-activated protein kinase 3 Antibody
|
Verified Applications
|
Immunodepletion, Immunocompetition
|
Peptide Description
|
Synthetic peptide taken within amino acid region 300-350 on human Mitogen-activated protein kinase 3.
|
Physical Properties
|
|
Quantity
|
250 µg
|
Volume
|
100 µl
|
Form
|
Antigenic Blocking Peptide
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Competition/Depletion assay
|
Refer to competition assay protocol
|
Protein
|
Uniprot #
|
P27361
|
Overview
|
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.
|
Molecular Function
|
Kinase, Serine/threonine-protein kinase, Transferase
|
Subcellular Location
|
Cytoplasm, Nucleus
|
Structure
|
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
|
Alternative Nomenclature
|
Mitogen-activated protein kinase 3 Antibody MAP kinase 3 Antibody
MAPK 3 Antibody
ERT2 Antibody
Extracellular signal-regulated kinase 1 Antibody ERK-1 Antibody
Insulin-stimulated MAP2 kinase Antibody
MAP kinase isoform p44 Antibody p44-MAPK Antibody Microtubule-associated protein 2 kinase Antibody
p44-ERK1 Antibody
MAPK3 Antibody
ERK1 Antibody
PRKM3 Antibody
|
|
|