General Information |
|
Product |
MLKL Antibody BIOTIN |
Description |
BIOTIN-Conjugated Mixed lineage kinase domain-like protein MLKL Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to amino acids within region 400-450 on mouse Mixed lineage kinase domain-like protein MLKL. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
BIOTIN-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20?C for long term storage |
|
|
ELISA |
1:50,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). |
Molecular Function |
ATP binding identical protein binding JUN kinase kinase kinase activity protein-containing complex binding protein kinase activity protein kinase binding |
Subcellular Location |
Nucleus, Plasma membrane, cytoplasm |
Structure |
Homooligomer (PubMed:29883610). Homotrimer; forms homotrimers on necroptosis induction (PubMed:24316671). Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK1 and RIPK3 (PubMed:22265414). Within this complex, may play a role in the proper targeti |
Alternative Nomenclature |
9130019I15Rik antibody FLJ34389 antibody hMLKL antibody Mixed lineage kinase domain like antibody Mixed lineage kinase domain like pseudokinase antibody Mixed lineage kinase domain-like protein antibody Mlkl antibody MLKL_HUMAN antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
MLKL-101AP | |||
|
MLKL-FITC | |||
|
P-MLKL | |||
|
PC-MLKL | |||
Display accessory details |
Select your currency:
(c) FabGennix International Inc.