General Information |
|
Product |
SorLA Antibody FITC-Conjugated |
Description |
FITC-Conjugated Sortilin-related receptor Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 2100-2200 on human SORLA receptor protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.50-0.62 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems. |
Molecular Function |
beta-amyloid binding, low-density lipoprotein particle binding |
Subcellular Location |
membrane, single-pass type I membrane protein, golgi apparatus, secreted |
Expression |
Abundant in brain, where it is mainly expressed in adult cerebellum, hippocampal ca regions, dentate gyrus, and to a much lesser extent in the cerebral cortex. Detectable in kidney, skeletal muscle, lung and spleen, but not in the liver. |
Alternative Nomenclature |
C11orf32 antibody gp250 antibody LDLR relative with 11 ligand binding repeats antibody Low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody LR11 antibody LRP9 antibody Mosaic protein LR11 antibody SORL1 antibody SorLA 1 antibody Sortilin related receptor antibody Sorting protein related receptor containing LDLR class A repeats antibody Sorting protein-related receptor containing |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
SORLA-101AP | |||
|
P-SORLA | |||
|
SORLA-BIOTIN | |||
|
PC-SORLA | |||
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