General Information |
|
Product |
RUNX1 / AML1 Antibody FITC-Conjugated |
Description |
FITC-Conjugated RUNX1 Protein Antibody |
Verified Applications |
ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Bovine, Human, Monkey |
Immunogen |
Synthetic peptide taken within amino acid region 1-80 on human RUNX1 protein. |
Accession # |
GenBank: AAI36381.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.51-0.53 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
WB |
1:10,000 |
ELISA |
1:10,000 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. |
Molecular Function |
ATP binding, DNA binding, calcium ion binding |
Subcellular Location |
Nucleus |
Expression |
Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood. |
Structure |
Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. |
Alternative Nomenclature |
Acute myeloid leukemia 1 protein antibody alpha subunit core binding factor antibody AML1 EVI 1 fusion protein antibody Aml1 oncogene antibody AMLCR 1 antibody CBF alpha 2 antibody Core binding factor runt domain alpha subunit 2 antibody Core-binding factor subunit alpha-2 antibody EVI1 antibody HGNC antibody Oncogene AML 1 antibody PEBP2 alpha B antibody Polyomavirus enhancer binding protein 2 alpha B subunit antibody Run1 antibody Runt-related transcription factor 1 antibody SL3/AKV core binding factor alpha B subunit antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
RUNX1-101AP | |||
|
P-RUNX1 | |||
|
RUNX1-BIOTIN | |||
|
PC-RUNX1 | |||
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