General Information
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Product
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Legumain Positive Control
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Verified Applications
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WB
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Immunogen
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Purified protein.
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Accession #
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NCBI: XP_016876954
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Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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Form
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Western Blot Positive Control
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Storage
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-20⁰C for long term storage
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Application Protocol
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Western Blot
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1:500
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Protein
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Uniprot #
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Q99538
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Overview
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Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
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Subcellular Location
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Lysosome
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Expression
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Ubiquitous. Particularly abundant in kidney, heart and placenta.
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Structure
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In the zymogen form, the uncleaved propeptide blocks access to the active site.
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Alternative Nomenclature
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AEP antibody
Asparaginyl endopeptidase antibody
cysteine 1 antibody
Cysteine protease 1 antibody
Legumain antibody
LGMN antibody
LGMN1 antibody
Protease antibody
Protease cysteine 1 (legumain) antibody
Protease cysteine 1 antibody
PRSC1 antibody
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