General Information
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Product
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Phospho-TICAM2 Peptide
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Description
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Antigenic Blocking Peptide Phosphorylated TRIF-related adapter molecule Antibody
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Verified Applications
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Immunocompeition, Immunodepletion
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Peptide Description
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Phosphorylated synthetic peptide corresponding to unique amino acid sequences on TRIF-related adapter molecule protein.
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Accession #
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GenBank: AAO74498.1
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q86XR7
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Overview
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Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4.
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Molecular Function
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phospholipid binding, signal transducer activity
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Subcellular Location
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Isoform 1 : Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic reticulum. Early endosome membrane. Late endosome membrane
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Expression
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Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
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Structure
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Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs in late endosomes and dirupts the interaction between isoform 1 and TICAM1. Interacts with MYD88; the interaction decreases after IL-18 stimulation in time-dependent manner. Interacts with IL18R1 and IL8RAP.
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Alternative Nomenclature
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Putative NF-kappa-B-activating protein 502 antibody
TIR containing adapter molecule 2 antibody
TIR domain containing adaptor protein antibody
TIRAP3 antibody
TIRP antibody
Toll-like receptor adaptor protein 3 antibody
Toll/interleukin-1 receptor domain-containing protein antibody
TRAM antibody
TRIF-related adapter molecule antibody
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