General Information |
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Product |
MERTK Peptide |
Description |
Antigenic Blocking Peptide Human cellular proto-oncogene (c-mer) Antibody C-epitope |
Verified Applications |
Immunocompetition, Immunodepletion |
Peptide Description |
Synthetic peptide taken within amino acid region 900-994 on MerTK protein. |
Accession # |
NCBI: NP_075232 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Uniprot # |
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Overview |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity). |
Molecular Function |
Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Membrane; Single-pass type I membrane protein |
Expression |
Is expressed in many neoplastic B- and T-cells. Is expressed highly in testis, ovary, prostate, lung and kidney and is expressed at low levels in the spleen, small intestine, colon and liver. |
Structure |
Interacts with TNK2 upon activation. Interacts with extracellular ligands LGALS3, TUB, TULP1, and GAS6. |
Alternative Nomenclature |
c MER antibody c mer proto oncogene tyrosine kinase antibody Eyk antibody MER antibody MER receptor tyrosine kinase antibody MERK antibody MERPEN antibody Mertk antibody MERTK c-mer proto-oncogene tyrosine kinase antibody MGC133349 antibody nmf12 antibody Nyk antibody Proto oncogene tyrosine protein kinase MER antibody Proto-oncogene c-Mer antibody Receptor tyrosine kinase MerTK antibody RP38 antibody STK kinase antibody Tyrosine-protein kinase Mer antibody |
Protein information supplied by UniProt
Fabgennix MerTK Antibody has been used in 17 Publications |
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Western Blot; Rat |
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Immunofluorescence; Mouse |
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Immunohistochemistry; Mouse |
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Western Blot; Mouse |
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Western Blot; Mouse |
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Western Blot; Human, Mouse |
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Western Blot; Mouse |
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Immunoprecipitation; Mouse |
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Immunoprecipitation; Mouse |
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Western Blot; Human |
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Western Blot; Mouse |
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Western Blot; Mouse |
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Immunohistochemistry, Western Blot; Human, Mouse |
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Immunoprecipitation, Western Blot; Human |
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Flow Cytometry; Human, Mouse |
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Flow Cytometry; Mouse |
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Immunoprecipitation, Western Blot; Mouse |
Publishing research using MKT-101AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
MKT-101AP | $320.00 * | ||
|
MKT100-FITC | $375.00 * | ||
|
MKT100-BIOTIN | $375.00 * | ||
|
PC-MKT | $220.00 * | ||
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(c) FabGennix International Inc.