General Information

Product

ACTH Antibody

Description

Affinity Purified Adrenocorticotropin Hormone Antibody

Verified Applications

ELISA, IHC-Fr, IHC-P, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Predicted: Chicken, Chimpanzee, Cow, Dog, Goat, Guinea pig, Macaque Monkey, Orangutan, Sheep

Immunogen

Synthetic peptide corresponding to ACTH aa 138-176. 

Sequence:

SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF

Accession #

NCBI:  AAX36901

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.67-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Immunocytochemistry

1:250

Immunofluorescence

1:200

Immunohistochemistry

1:250

Immunoprecipitation

1:200

Western Blot

1:1000 Predicted Molecular weight: 29 kDa

Protein

Uniprot #

UPI00004EBE53

Overview

Stimulates adrenal glands and release cortisol.

Molecular Function

GPCR; Hormone activity

Subcellular Location

Secreted

Expression

ACTH and MSH are produced by the pituitary gland

Structure

Belongs to POMC family

Alternative Nomenclature

Alpha Melanocyte Stimulating Hormone antibody

Beta Endorphin antibody

Beta Lipotropin antibody

Beta Melanocyte Stimulating Hormone antibody

Beta-endorphin antibody

CLIP antibody

Corticotropin Like Intermediary Peptide antibody

Met-enkephalin antibody

MSH antibody

NPP antibody

Opiomelanocortin prepropeptide antibody

POC antibody

POMC antibody

Tetracosactide antibody

General Information

Product

Calcium Sensing Receptor Antibody

Description

Affinity Purified extracellular calcium-sensing receptor Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Predicted: Rabbit, Horse, Chicken, Cow, Dog, Chimpanzee, Macaque Monkey

Immunogen

Synthetic peptide corresponding to amino acids 47-69 on human CASR gene.

Sequence:

KDQDLKSRPESVECIRYNFRGFR

Accession #

NCBI: NP_000379.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500. Predicted molecular weight: 121 kDa

Protein

Uniprot #

P41180

Overview

Senses change in extracellular concentration of calcium channels.

Molecular Function

GPCR, Receptor, Transducer.

Subcellular Location

Cell membrane; Mulipass membrane protein.

Expression

Temporal lobe, frontal lobe, parietal lobe, hippocampus, cerebellum, kidney, lung, liver, heart, skeletal muscle and placenta.

Structure

Interacts with VCP, RNF19A and ARRB1.

Alternative Nomenclature

CAR antibody

EIG8 antibody

FHH antibody

FIH antibody

GPRC2A antibody

HHC1 antibody

Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism antibody

NSHPT antibody

Parathyroid Cell calcium-sensing receptor antibody

PCAR1 antibody

General Information

Product

Norepinephrine Transporter Antibody

Description

Affinity Purified Sodium -dependent noradrenaline transporter Antibody

Verified Applications

Dot Blot, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to N-terminal amino acids that are unique to noradrenaline transporter protein. The antibodies are raised utilizing linear, multiple antigenic peptides or cyclic peptide methodology.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage Instructions

Shipped at 4⁰C. Upon delivery aliquot and store at -20⁰C or -80⁰C. Avoid repeated freeze / thaw cycles.

pH: 7.80
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris glycine, 30% Glycerol

Application Protocol

Confocal Microscopy

1:100

DB

1:4,000

ELISA

1:4,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:250

Protein

Uniprot #

P23975

Overview

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Molecular Function

monoamine transmembrane transporter activity; norepinephrine:sodium symporter activity

Subcellular Location

Membrane

Expression

Adrenal gland; Placenta; Testis; Skin

Structure

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.

Alternative Nomenclature

NAT1 antibody

NET antibody

NET1 antibody

Neurotransmitter transporter antibody

Norepinephrine transporter antibody

SLC6A2 antibody

SLC6A5 antibody

Sodium dependent noradrenaline transporter antibody

Solute carrier family 6 (neurotransmitter transporter norepinephrine) member 5 antibody

Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 antibody

Solute carrier family 6 member 2 antibody

Solute carrier family 6 member 5 antibody

General Information

Product

NPY5R Antibody Affinity Purified

Description

Affinity Purified Neuropeptide Y receptor type 5 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on NPY5R protein.

Accession #

NCBI: NP_006165.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q15761

Overview

Receptor for neuropeptide Y and peptide YY,associated with food intake. Could be involved in feeding disorders.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Membrane

Expression

Brain; hypothalamus.

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

Neuropeptide Y receptor type 5 antibody

NPY 5R antibody

NPYY5 antibody

NPYY5-R antibody

Y5 receptor antibody

General Information

Product

Orexin A Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on ORXN protein.

Accession #

NCBI: NP_034540

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O55241

Overview

Is a portion of a protein complex (ribonuclease P) that creates mature tRNA molecues through the cleavage of their 5' ends.

Molecular Function

ribonuclease P activity, Endonuclease, Hydrolase, Nuclease

Subcellular Location

Cytoplasm

Structure

Contains a catalytic RNA component and at least 4 to 5 protein subunits.

Alternative Nomenclature

HCRT 1 antibody

HCRT antibody

HCRT2 antibody

Hypocretin 1 antibody

Hypocretin 2 antibody

Hypocretin antibody

Hypocretin neuropeptide precursor antibody

NRCLP1 antibody

Orexin A antibody

Orexin antibody

Orexin B antibody

OX antibody

PPORX antibody

PPOX antibody

PREPROOREXIN antibody

General Information

Product

proBNP Antibody

Description

Affinity Purified Gamma-brain natriuretic peptide Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 100-150 on human proBNP.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.8 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P16860

Overview

A cardiac hormone that may also serve as a paracrine antifibrotic factor in the heart.  Also functions in cardiovascular homeostasis via natriuresis, diuresis, vasorelaxation, and the inhibition of renin and aldosterone secretion.

Molecular Function

Diuretic hormone activity, Hormone, Vasoactive

Subcellular Location

Secreted

Expression

Is expressed in the brain and atria, however it is expressed at much lower levels than ANP.

Alternative Nomenclature

BNP 32 antibody

BNP antibody

BNP(1-32) antibody

BNP(5-29) antibody

Brain Natriuretic Peptide 32 antibody

Gamma brain natriuretic peptide antibody

Natriuretic peptide precursor type B antibody

NPPB antibody

General Information

Product

TORC2 Antibody

Description

Affinity Purified CREB-regulated transcription coactivator 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 640-693 on human CREB-regulated transcription coactivator 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q53ET0

Overview

Activator, cAMP response element binding protein binding

Subcellular Location

Cytoplasm, Nucleus

Expression

Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle.

Alternative Nomenclature

CREB regulated transcription coactivator 2 antibody

CRTC2 antibody

TORC-2 antibody

Transducer of CREB protein 2 antibody

Transducer of regulated cAMP response element-binding protein antibody

Immunoprecipitation

General Information

Product

Estrogen Receptor alpha Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 30-80 on human ESTRA protein

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P03372

Overview

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Molecular Function

Activator, Receptor

Subcellular Location

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

Expression

Widely expressed. Isoform 3 is not expressed in the pituitary gland

Structure

Belongs to the nuclear hormone receptor family. NR3 subfamily

Alternative Nomenclature

DKFZp686N23123 antibody

ER alpha antibody

ER antibody

Era antibody

ESR antibody

ESR1 antibody

ESRA antibody

Estradiol receptor antibody

Estrogen nuclear receptor alpha antibody

Estrogen receptor 1 antibody

Estrogen receptor antibody

ESTRR antibody

Major ORF antibody

NR3A1 antibody

Nuclear receptor subfamily 3 group A member 1 antibody

General Information

Product

Pannexin 1 Antibody

Description

Affinity Purified ECEL1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region from human Pannexin 1  protein

Accession #

GenBank: AAQ89282.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O95672

Overview

May play a role in the degradation of peptide hormones.  It also may contribute to the inactivation of neuronal peptides.

Subcellular Location

Membrane; Single-pass type II membrane protein

Alternative Nomenclature

innexin antibody

MRS1 antibody

Pannexin 1 antibody

Panx1 antibody

UNQ2529 antibody

General Information

Product

PGCB Antibody

Description

Affinity Purified Atrial natriuretic peptide receptor 2 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase B protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:50-1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P20594

Overview

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.

Molecular Function

ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family.  Contains 1 guanylate cyclase domain.  Contains 1 protein kinase domain.

Alternative Nomenclature

AMDM antibody

ANPB antibody

ANPRB antibody

peptide receptor type B antibody

Atrionatriuretic peptide receptor B antibody

GC-B antibody

GUCY2B antibody

Natriuretic peptide receptor B/guanylate cyclase B antibody

NPR-B antibody

NPR2 antibody

NPRBi antibody