General Information |
|
Product |
MAPK8 Peptide |
Description |
Antigenic Blocking Peptide Mitogen-activated protein kinase 8 Antibody |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 370-420 on human Mitogen-activated protein kinase 8. |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Immunohistochemistry | 1:50-1:100 |
Competition/Depletion assay |
1:500 |
|
|
Uniprot # |
|
Overview |
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. |
Molecular Function |
Kinase, Serine/threonine-protein kinase, Transferase |
Subcellular Location |
Cytoplasm, Nucleus |
Structure |
Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells. Interacts with NFATC4. Interacts with MECOM; regulates JNK signaling. Interacts with PIN1; this interaction mediates MAPK8 conformational changes leading to the binding of MAPK8 to its substrates. |
Alternative Nomenclature |
AI849689 antibody c Jun N terminal kinase 1 antibody JNK 1 antibody JNK-46 antibody JNK1A2 antibody JNK21B1/2 antibody MAP kinase 8 antibody MAPK 8 antibody Mitogen-activated protein kinase 8 antibody p54 gamma antibody Prkm8 antibody Protein kinase JNK1 antibody Protein kinase, mitogen-activated, 8 antibody SAPK 1 antibody SAPK gamma antibody Stress-activated protein kinase 1 antibody Stress-activated protein kinase JNK1 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
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MAPK8-101AP | |||
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MAPK8-BIOTIN | |||
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MAPK8-FITC | |||
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PC-MAPK8 | |||
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