General Information |
|
Product |
TMEM173 Peptide |
Description |
Antigenic Blocking Peptide Stimulator of interferon genes protein isoform 1 |
Verified Applications |
Immunocompetition, Immunodepletion |
Peptide Description |
Synthetic peptide corresponding to amino acid region 332-342. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to a carrier protein using hetero bifunctional cross linker.
Sequence: SFSLLSSQEVLRHLLRQEEKEEVT |
Accession # |
NCBI: NP_938023 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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|
Competition/Depletion assay |
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Uniprot # |
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Overview |
Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. |
Molecular Function |
cyclic-di-GMP binding, cyclic-GMP-AMP binding, identical protein binding |
Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm › perinuclear region. Cytoplasm |
Expression |
Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages. |
Structure |
Associates with the MHC-II complex (By similarity). Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2. |
Alternative Nomenclature |
endoplasmic reticulum IFN stimulator antibody ERIS antibody FLJ38577 antibody Mediator of IRF3 activation antibody MITA antibody Mitochondrial mediator of IRF3 activation antibody MPYS antibody N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody NET23 antibody Stimulator of interferon genes antibody STING antibody Tmem173 antibody Transmembrane protein 173 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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STING-101AP | |||
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STING-FITC | |||
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STING-BIOTIN | |||
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PC-STING | |||
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