General Information |
|
Product |
TICAM2 Antibody FITC-Conjugated |
Description |
FITC-Conjugated TRIF-related adapter molecule Antibody |
Verified Applications |
DB, ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to unique amino acid sequences on TRIF-related adapter molecule. |
Accession # |
GenBank: AAO74498.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.50-0.75 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:20,000 |
ELISA |
1:20,000 |
Western Blot |
1:500-1:750 |
|
|
Uniprot # |
|
Overview |
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. |
Molecular Function |
phospholipid binding, signal transducer activity |
Subcellular Location |
Isoform 1 : Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic reticulum. Early end |
Expression |
Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1). |
Structure |
Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs i |
Alternative Nomenclature |
Putative NF-kappa-B-activating protein 502 antibody TICAM2 antibody TIR containing adapter molecule 2 antibody TIR domain-containing adapter molecule 2 antibody TIRAP3 antibody TIRP antibody Toll-like receptor adaptor protein 3 antibody Toll/interleukin-1 receptor domain-containing protein antibody TRAM antibody TRIF-related adapter molecule antibody |
Protein information supplied by UniProt
Fabgennix TRIF adapter molecule Antibody has been used in 2 Publications |
|
Keck, Simone, et al. "Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells." The Journal of Immunology 186.9 (2011): 5478-5488. PMID21441453
|
Western Blot; Mouse |
Fischer, Hans et al. “Pathogen Specific, IRF3-Dependent Signaling and Innate Resistance to Human Kidney Infection.” Ed. Frederick M. Ausubel.PLoS Pathogens 6.9 (2010): e1001109. PMC2944801
|
Western Blot; Human, Mouse |
Publishing research using TRAM-101AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
TRAM-101AP | |||
|
P-TRAM | |||
|
TRAM-BIOTIN | |||
|
PC-TRAM | |||
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