General Information |
|
Product |
PERK Antibody FITC-Conjugated |
Description |
FITC-Conjugated Eukaryotic translation initiation factor 2-alpha kinase 3 Antibody |
Verified Applications |
DB, ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1000-1050 on human Eukaryotic translation initiation factor 2-alpha kinase 3 protein. |
Accession # |
NCBI: NP_004827 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.68-0.70 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Dot Blot |
1:4,000 |
ELISA |
1:4,000 |
Immunohistochemistry | 1:50-1:100 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. |
Molecular Function |
Kinase, Serine/threonine-protein kinase, Transferase |
Subcellular Location |
Endoplasmic reticulum membrane; Single-pass type I membrane protein |
Expression |
Ubiquitous. A high level expression is seen in secretory tissues. |
Structure |
Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3 and MFN2. |
Alternative Nomenclature |
Eif2ak3 antibody Eukaryotic translation initiation factor 2 alpha kinase 3 antibody Heme regulated EIF2 alpha kinase antibody HRI antibody HsPEK antibody Pancreatic eIF2 alpha kinase antibody PEK antibody PRKR like endoplasmic reticulum kinase antibody WRS antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
PERK-101AP | |||
|
PERK-BIOTIN | |||
|
P-PERK | |||
|
PC-PERK | |||
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