General Information
|
|
Product
|
FXIIIA Antibody BIOTIN-Conjugated
|
Description
|
BIOTIN-Conjugated Blood coagulation factor XIII a subunit Antibody Multi-epitope
|
Verified Applications
|
CM, ELISA, ICC, IHC, IF, IP, WB
|
Host
|
Rabbit
|
Species Cross Reactivity
|
Human
|
Immunogen
|
Multi-epitope synthetic peptides were used: amino acid range 1-50 and 700-732. A mixture of synthetic peptides used for FXIIIA-101AP and FXIIIA-112AP.
|
Accession #
|
GenBank: AAA52415.1
|
Physical Properties
|
|
Quantity
|
100 µg
|
Volume
|
200 µl
|
Concentration
|
0.55-0.75 µg/µl in antibody stabilization buffer
|
Form
|
BIOTIN-Conjugated
|
Determinant |
Multi-epitope |
Clonality
|
Polyclonal
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Confocal Microscopy
|
1:200
|
DB
|
1:10,000
|
ELISA
|
1:10,000
|
Immunocytochemistry
|
1:200
|
Immunofluorescence
|
1:200
|
Immunohistochemistry
|
1:200
|
Immunoprecipitation
|
1:150
|
Western Blot
|
1:500
|
Protein
|
Uniprot #
|
P00488
|
Overview
|
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
|
Molecular Function
|
Metal ion binding; Protein-glutamine gamma-glutamyltransferase activity
|
Subcellular Location
|
Cytoplasm. Secreted
|
Structure
|
Tetramer of two A chains and two B chains.
|
Alternative Nomenclature
|
Coagulation factor XIII A chain antibody
F13A antibody
Factor XIIIA antibody
Fibrin stabilizing factor, A subunit antibody
Fibrinoligase antibody
FSF, A subunit antibody
TGase antibody
Transglutaminase A chain antibody
Transglutaminase. plasma antibody
|
|
|