MeCP2 isoform 1 Antibody

Product no.: MECP2E1-101AP
$285.00


General Information

 

 

Product

 

MeCP2 isoform 1 Antibody

Description

Affinity Purified Methyl-CpG-binding protein 2 isoform 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on mouse methyl-CpG-binding protein 2 isoform 1.

Accession #

NCBI:  NP_004983


Physical Properties

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

 

ELISA

 

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000


Protein

 

Uniprot #

 

P51608

Overview

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

Molecular Function

Chromatin binding, DNA binding, mRNA binding, double-stranded methylated DNA binding, poly(A) RNA binding, siRNA binding

Subcellular Location

Nucleus (Note: Colocalized with methyl-CpG in the genome)

Structure

Interacts with FNBP3. Interacts with CDKL5 (PubMed:15917271). Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells. Interacts with NCOR2.

Expression

Present in all adult somatic tissues tested.

Alternative Nomenclature

AUTSX 3 antibody

Mbd5 antibody

MeCP-2 protein antibody

MeCP2 antibody

Methyl CpG binding protein 2 (Rett syndrome) antibody

Methyl CpG binding protein 2 antibody

MRX 16 antibody

MRX 79 antibody

MRXS13 antibody

MRXSL antibody

PPMX antibody

RS antibody

RTS antibody

RTT antibody

WBP 10 antibody

Protein information supplied by UniProt.


Accessories

Product Note Status Price
MeCP2 isoform 1 Antibody BIOTIN MeCP2 isoform 1 Antibody BIOTIN
MECP2E1-BIOTIN $375.00 *
MeCP2 isoform 1 Antibody FITC MeCP2 isoform 1 Antibody FITC
MECP2E1-FITC $375.00 *
MeCP2 isoform 1 Blocking Peptide MeCP2 isoform 1 Blocking Peptide
P-MECP2E1 $155.00 *
MeCP2 isoform 1 Positive Control MeCP2 isoform 1 Positive Control
PC-MECP2E1 $200.00 *
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