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General Information
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Product
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Phospho Survivin Antibody Affinity Purified
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Description
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Affinity Purified Phosphorylated Baculoviral IAP repeat-containing protein 5 isoform 2 Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Phosphorylated synthetic peptide corresponding to unique amino acid sequences on human Survivin protein.
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Accession #
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NCBI: NP_001012270.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.50-1.50 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Western Blot
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1:500
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Protein
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Uniprot #
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O15392
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Overview
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Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
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Molecular Function
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Protease inhibitor, Repressor, Thiol protease inhibitor
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Subcellular Location
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Cytoplasm, Nucleus, Chromsome, Centromere, Cytoskeleton, Spindle, Kinetochore, Midbody
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Expression
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Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
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Structure
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Monomer or Homodimer.
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Alternative Nomenclature
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API4 antibody
Apoptosis Inhibitor 4 antibody
Apoptosis inhibitor survivin antibody
Baculoviral IAP repeat-containing protein 5 antibody
BIRC5 antibody
EPR 1 antibody
IAP4 antibody
Survivin variant 3 alpha antibody
SVV antibody
TIAP antibody
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Phospho-Survivin Antibody FITC
Phospho-Survivin Antibody BIOTIN
Phospho-Survivin Blocking Peptide
Phospho-Survivin Positive Control
