General Information
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Product
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SIRT1 Antibody BIOTIN-Conjugated
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Description
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BIOTIN-Conjugated NAD-dependent protein deacetylase sirtuin-1 isoform 1 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Chicken, Human, Monkey, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid 25-75 on rat Sirtuin 1 protein.
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Accession #
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NCBI: NP_062786.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.69-0.75 µg/µl in antibody stabilization buffer
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Form
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BIOTIN-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunohistochemsitry |
1:100 |
Immunoprecipitation |
1:200 |
Western Blot
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1:500
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Protein
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Uniprot #
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Q923E4
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Overview
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NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autphagy.
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Subcellular Location
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Nucleus, PML body, cytoplasm. (Nucleus: Recruited to the nuclear bodies via its interaction with the PML. Colocalized with APEX1 in nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm).
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Expression
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Widely expressed. Weakly expressed in liver and skeletal muscle.
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Alternative Nomenclature
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75SirT1 antibody
HST2, S. cerevisiae, homolog of antibody
NAD dependent deacetylase sirtuin 1 antibody
Regulatory protein SIR2 homolog 1 antibody
SIR2 like protein 1 antibody
SIR2, S.cerevisiae, homolog-like 1 antibody
SIR2ALPHA antibody
SIR2L1 antibody
SirtT1 75 kDa fragment antibody
Sirtuin type 1 antibody
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