General Information
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Product
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Phospho-JAK2 Peptide
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Description
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Antigenic Blocking Peptide Phosphorylated Tyrosine-protein kinase JAK2 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 980-1030 on human JAK2 protein. Phosphorylated 1008 & 1009 tyrosine residues.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Modification |
Phosphorylated tyrosine 1008 & 1009. |
Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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O60674
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Overview
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Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor.
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Molecular Function
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Adaptive immunity, Immunity, Innate immunity
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Subcellular Location
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Endomembrane system; Peripheral membrane protein; Cytoplasm; Nucleus
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Expression
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Ubiquitously expressed throughout most tissues.
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Structure
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Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1.
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Alternative Nomenclature
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JAK 2
Janus Activating Kinase 2
Janus kinase 2 (a protein tyrosine kinase)
Janus kinase 2
JTK 10
THCYT3
Tyrosine protein kinase JAK2
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