General Information |
|
Product |
HIPK2 Antibody FITC |
Description |
FITC-Conjugated Homeodomain-interacting protein kinase 2 Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1150-1198 on human Homeodomain-interacting protein kinase 2 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:50,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:2,500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. |
Molecular Function |
ATP binding protein kinase activity protein serine/threonine kinase activity RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity SMAD binding transcription corepressor activity virion binding |
Subcellular Location |
Nucleus, PML body, Cytoplasm |
Expression |
Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors. |
Alternative Nomenclature |
HIPK 2 antibody Homeodomain interacting protein kinase 2 antibody Nbak1 antibody Nuclear body-associated kinase 1 antibody PRO0593 antibody Sialophorin tail-associated nuclear serine/threonine-protein kinase antibody Stank antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
HIPK2-201AP | |||
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HIPK2-BIOTIN | |||
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P-HIPK2 | |||
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PC-HIPK2 | |||
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