General Information
|
|
Product
|
MC4 Receptor Peptide
|
Description
|
Antigenic Blocking Peptide Melanocortin receptor 4
|
Verified Applications
|
Immunodepletion, Immunocompetition
|
Peptide Description
|
Synthetic peptide taken within amino acid region 10-60 on human MC4R protein.
|
Accession #
|
NCBI: NP_005903.2
|
Physical Properties
|
|
Quantity
|
250 µg
|
Volume
|
100 µl
|
Form
|
Antigenic Blocking Peptide
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Competition/Depletion assay
|
Refer to competition assay protocol
|
Protein
|
Uniprot #
|
P32245
|
Overview
|
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
|
Molecular Function
|
Melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, neuropeptide binding, ubiquitin protein ligase binding
|
Subcellular Location
|
cell membrane, multi-pass membrane protein, membrane raft. (Note: Localizes to membrane rafts but is also loated in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts)
|
Expression
|
Brain, placental, and gut tissues.
|
Alternative Nomenclature
|
MC4 R antibody
Melanocortin receptor 4 antibody
MGC126851 antibody
MGC138197 antibody
|
|
|