General Information |
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Product |
MAPK1 Positive Control |
Description |
Western Blot Positive Control Mitogen-activated protein kinase 1 Antibody |
Verified Applications |
WB |
Immunogen |
Purified protein |
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|
Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. |
Molecular Function |
Kinase, Repressor, Serine/threonine-protein kinase, Transferase |
Subcellular Location |
Cytoplasm › cytoskeleton › spindle By similarity Nucleus Cytoplasm › cytoskeleton › microtubule organizing center › centrosome Cytoplasm |
Structure |
Binds both upstream activators and downstream substrates in multimolecular complexes. Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, |
Alternative Nomenclature |
ERK antibody MAP kinase isoform p42 antibody Mapk1 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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MAPK1-101AP | |||
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MAPK1-BIOTIN | |||
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MAPK1-FITC | |||
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P-MAPK1 | |||
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