General Information

Product

SERINC5 Antibody

Description

Affinity Purified Serine incorporator 5 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 270-320 on human Serine incorporator 5 protein.

Accession #

NCBI:  XP_011541606

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

UPI0005D01C8F

Overview

Restriction factor required to restrict infectivity of gammaretroviruses, such as HIV-1: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).

Molecular Function

L-serine transmembrane transporter activity

Subcellular Location

Cell membrane; Multi-pass membrane

Expression

Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain.

Structure

Belongs to the TDE1 family

Alternative Nomenclature

C5orf12 antibody

SERC5_HUMAN antibody

SERINC5 antibody

Serine incorporator 5 antibody

TPO1 antibody

General Information

Product

ABHD2 Antibody

Description

Affinity Purified a/b hydrolase II Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on  mouse a/b hydrolase II protein.

Accession #

GenBank: AAQ12022.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q9QXM0

Overview

Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Involved in acrosomal reaction (PubMed:26989199). May also play a role in smooth muscle cells migration.

Molecular Function

Hydrolase, Serine esterase

Subcellular Location

Cell membrane; Single-pass type II membrane protein

Cytoplasmic vesicle › secretory vesicle › acrosome membrane

Expression

Widely expressed with higher expression in testis. Expressed by vascular smooth muscle cells, non vascular smooth muscle cells and heart.

Structure

Signal-anchor, Transmembrane, Transmembrane helix

Alternative Nomenclature

abhydrolase domain containing 2 antibody

alpha/beta hydrolase domain containing protein 2 antibody

HS1 2 antibody

LABH2 antibody

Lung alpha/beta hydrolase 2 antibody

PHPS1 2 antibody

protein PHPS1-2 antibody

General Information

Product

Aromatase Antibody

Description

Affinity Purified Aromatase Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-450 on human Aromatase protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P11511

Overview

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Molecular Function

aromatase activity

electron carrier activity

heme binding

iron ion binding

Subcellular Location

Membrane; Peripheral membrane protein

Expression

Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.

Structure

Belongs to the cytochrome P450 family.

Alternative Nomenclature

ARO antibody

ARO1 antibody

Aromatase antibody

CP19A_HUMAN antibody

CPV1 antibody

CYAR antibody

Cyp19a1 antibody

CYPXIX antibody

Cytochrome P-450AROM antibody

Cytochrome P450, family 19, subfamily A, polypeptide 1 antibody

Cytochrome P450, subfamily XIX (aromatization of androgens) antibody

Estrogen synthase antibody

Flavoprotein linked monooxygenase antibody

Microsomal monooxygena

450AROM antibody

General Information

Product

AMPK alpha 1 Antibody

Description

Affinity Purified 5'-AMP-activated protein kinase catalytic subunit alpha-1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 500-550 on rat 5'-AMP-activated protein kinase catalytic subunit alpha-1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P54645

Overview

Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.

Molecular Function

[acetyl-CoA carboxylase] kinase activity

[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

AMP-activated protein kinase activity

ATP binding

chromatin binding

Subcellular Location

Nucleus, Cytoplasm

Expression

Low expression in kidney, liver, lung, heart and brain.

Structure

The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.

Alternative Nomenclature

5 AMP activated protein kinase alpha 1catalytic subunit antibody

AAPK1 antibody

ACACA kinase antibody

acetyl CoA carboxylase kinase antibody

AMP -activate kinase alpha 1 subunit antibody

AMPK 1 antibody

AMPK alpha 1 antibody

HMG CoA reductase kinase antibody

HMGCR kinase antibody

hormone sensitive lipase kinase antibody

Hydroxymethylglutaryl CoA reductase kinase antibody

im:7154392 antibody

kinase AMPK alpha1 antibody

PRKAA 1 antibody

Protein kinase AMP activated alpha 1 catalytic subunit antibody

SNF1A antibody

Tau protein kinase PRKAA1 antibody

General Information

Product

AMPK alpha 2 Antibody

Description

Affinity Purified 5'-AMP-activated protein kinase catalytic subunit alpha-2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 480-530 on rat 5'-AMP-activated protein kinase catalytic subunit alpha-2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q09137

Overview

Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.

Molecular Function

[acetyl-CoA carboxylase] kinase activity

[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

AMP-activated protein kinase activity

ATP binding Source: RGD

chromatin binding

histone serine kinase activity

metal ion binding -KW

protein binding

Subcellular Location

Nucleus, Cytoplasm

Expression

Skeletal muscle, lower levels in liver, heart and kidney.

Structure

The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.

Alternative Nomenclature

5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody

ACACA kinase antibody

Acetyl-CoA carboxylase kinase antibody

AMPK alpha 2 chain antibody

AMPK subunit alpha-2 antibody

AMPK2 antibody

AMPKa2 antibody

HMGCR kinase antibody

Hydroxymethylglutaryl-CoA reductase kinase antibody

PRKAA antibody

PRKAA2 antibody

Protein kinase AMP activated alpha 2 catalytic subunit antibody

General Information

Product

GBA Antibody

Description

Affinity Purified Glucosylceramidase Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Recombinant Glucosylceramidase protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P04062

Overview

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PubMed:9201993, PubMed:24211208). Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation (PubMed:19279011). Also plays a role in cholesterol metabolism (PubMed:24211208, PubMed:26724485). May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol (PubMed:24211208, PubMed:26724485). The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction (PubMed:24211208). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (PubMed:26724485). Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol (PubMed:24211208, PubMed:26724485).

Molecular Function

glucosylceramidase activity

glucosyltransferase activity

hydrolase activity

scavenger receptor binding

signaling receptor binding

steryl-beta-glucosidase activity

Subcellular Location

Lysosome

Expression

Interacts with saposin-C (PubMed:10781797). Interacts with SCARB2 (PubMed:18022370). Interacts with TCP1 (PubMed:21098288). May interact with SNCA; may inhibit the glucosylceramidase activity (PubMed:23266198). Interacts with GRN; this interaction prevents aggregation of GBA-SCARB2 complex via interaction with HSPA1A upon stress (PubMed:27789271).

Structure

Belongs to the glycosyl hydrolase 30 family.

Alternative Nomenclature

Lysosomal acid glucosylceramidase

General Information

Product

GAPDH Antibody

Description

Affinity Purified Glyceraldehyde-3-Phosphate dehydrogenase isoform 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 on mouse Glyceraldehyde-3-phosphate dehydrogenase protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20?C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500-1:5,000

Protein

Uniprot #

P16858

Overview

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively

Molecular Function

Oxidoreductase, Transferase

Subcellular Location

Cytoplasm, Cytoskeleton, Nucleus

Expression

brain;cerebullum;heart;kidney;liver;skeletal muscle

Structure

Homotetramer

Alternative Nomenclature

AI747587 antibody

cytoplasmic antibody

EC 1.1.1.8 antibody

FLJ26652 antibody

G3PD antibody

Gdc-1 antibody

Gdp1 antibody

Glycerol 3 phosphate dehydrogenase 1 antibody

Glycerol 3 phosphate dehydrogenase cytosolic antibody

Glycerol 3 phosphate dehydrogenase soluble antibody

Glycerol-3-phosphate dehydrogenase [NAD+] antibody

Glycerphosphate dehydrogenase antibody

GPD-C antibody

gpd1 antibody

Gpd3 antibody

GPDA_HUMAN antibody

Gpdc antibody

GPDH antibody

GPDH-C antibody

HTGTI antibody

KIAA4010 antibody

MGC93453 antibody

MGPD antibody

mKIAA4010 antibody

General Information

Product

GAPDH Antibody

Description

Affinity Purified Glyceraldehyde-3-Phosphate dehydrogenase isoform 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 250-300 on human Glyceraldehyde-3-phosphate dehydrogenase protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20?C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500-1:5,000

Protein

Uniprot #

P04406

Overview

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively

Molecular Function

Oxidoreductase, Transferase

Subcellular Location

Cytoplasm, Cytoskeleton, Nucleus

Expression

brain;cerebullum;heart;kidney;liver;skeletal muscle

Structure

Homotetramer

Alternative Nomenclature

AI747587 antibody

cytoplasmic antibody

EC 1.1.1.8 antibody

FLJ26652 antibody

G3PD antibody

Gdc-1 antibody

Gdp1 antibody

Glycerol 3 phosphate dehydrogenase 1 antibody

Glycerol 3 phosphate dehydrogenase cytosolic antibody

Glycerol 3 phosphate dehydrogenase soluble antibody

Glycerol-3-phosphate dehydrogenase [NAD+] antibody

Glycerphosphate dehydrogenase antibody

GPD-C antibody

gpd1 antibody

Gpd3 antibody

GPDA_HUMAN antibody

Gpdc antibody

GPDH antibody

GPDH-C antibody

HTGTI antibody

KIAA4010 antibody

MGC93453 antibody

MGPD antibody

mKIAA4010 antibody