General Information
|
|
Product
|
ATG16L1 Positive Control
|
Description
|
Western Blot Positive Control Autophagy-related protein 16-1 Antibody
|
Verified Applications
|
WB
|
Immunogen
|
Purified protein
|
Physical Properties
|
|
Quantity
|
5 Applications
|
Volume
|
Inquire
|
Form
|
Western Blot Positive Control
|
Purification Method
|
Immobilized antigen affinity chromatography
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Western Blot
|
1:500
|
Protein
|
Uniprot #
|
Q676U5
|
Overview
|
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
|
Molecular Function
|
Identical protein binding, Ubiquitin-like protein transferase activity
|
Subcellular Location
|
Cytoplasm, Preautophagosomal structure membrane, Peripheral membrane protein
|
Structure
|
Homooligomer. Interacts with WIPI2, FIP200 and ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Interacts with RAB33B. Interacts with TMEM
|
Alternative Nomenclature
|
APG16 like 1 antibody
APG16L antibody
APG16L beta antibody
ATG16 autophagy related 16 like 1 antibody
ATG16A antibody
ATG16L antibody
Autophagy related protein 16 1 antibody
IBD10 antibody
WD repeat domain 30 antibody
WDR30 antibody
|
|
|