General Information |
|
Product |
MOR1 Peptide |
Description |
Antigenic Blocking Peptide Mu-type opioid receptor isoform MOR-1i Antibody |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 405-455 on human Mu-type opiod receptor isoform MOR-1i protein. |
Accession # |
NCBI: NP_001272453 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
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Uniprot # |
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Overview |
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. |
Molecular Function |
G-protein coupled receptor, Receptor, Transducer |
Subcellular Location |
Cell membrane > Multi-pass membrane protein. Isoform 12: Cytoplasm |
Expression |
Expressed in brain. Isoform 16 and isoform 17 are detected in brain. |
Structure |
Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS. Interacts with GPM6A, RTP4, SYP, GNAS, RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1. |
Alternative Nomenclature |
hMOP antibody LMOR antibody M-OR-1 antibody MOP antibody MOR antibody MOR-1 antibody Mu opiate receptor antibody Mu opioid receptor antibody Opioid receptor mu 1 antibody OPRM antibody OPRM1 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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MOR1-101AP | |||
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MOR1-BIOTIN | |||
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MOR1-FITC | |||
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PC-MOR1 | |||
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