General Information
|
|
Product
|
VPS29 Peptide
|
Verified Applications
|
Immunocompetition, Immunodepletion
|
Peptide Description
|
Synthetic peptide taken within amino acid region 133-183 on rat Vacuolar Protein Sorting-Associated Protein 29.
|
Accession #
|
NCBI: NP_001099402.1
|
Physical Properties
|
|
Quantity
|
250 µg
|
Volume
|
100 µl
|
Form
|
Antigenic Blocking Peptide
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Competition/Depletion assay
|
Refer to competition assay protocol
|
Protein
|
Uniprot #
|
Q9UBQ0
|
Overview
|
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.
|
Molecular Function
|
Metal ion binding, Phosphoserine phosphatase activity
|
Subcellular Location
|
Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome Curated. Late endosome
|
Expression
|
Ubiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain.
|
Structure
|
Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed:11102511, PubMed:16737443, PubMed:17891154). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (By similarity). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants.
|
Alternative Nomenclature
|
DC15 antibody
DC7 antibody
DKFZp564F0223 antibody
FLJ20492 antibody
hVPS29 antibody
PEP11 antibody
Retromer protein antibody
Vacuolar protein sorting 29 antibody
Vacuolar sorting protein VPS29/PEP11 antibody
Vesicle protein sorting 29 antibody
VPS 29 antibody
x 007 protein antibody
|
|
|