General Information |
|
Product |
IRF8 Antibody BIOTIN |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 350-400 on mouse Interferon Regulatory Factor 8 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
BIOTIN-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:50,000 |
Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation |
1:200 |
Western Blot |
1:2,500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (PubMed:22992524). |
Molecular Function |
DNA binding DNA binding transcription factor activity RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
Subcellular Location |
Nucleus, cytoplasm |
Expression |
Predominantly in lymphoid tissues. |
Structure |
Belongs to the IRF family. |
Alternative Nomenclature |
H ICSBP antibody HICSBP antibody ICSBP 1 antibody Interferon consensus sequence binding protein 1 antibody Interferon regulatory factor 8 antibody IRF 8 antibody MYLS antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
IRF8M-101AP | |||
|
IRF8M-FITC | |||
|
P-IRF8M | |||
|
PC-IRF8M | |||
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