General Information |
|
Product |
MYLK Peptide |
Description |
Antigenic Blocking Peptide Myosin light chain kinase, smooth muscle isoform 1 |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 1870-1907 on human Myosin light chain kinase, smooth muscle isoform 1 protein. |
Accession # |
NCBI: NP_444253.3 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Uniprot # |
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Overview |
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. |
Molecular Function |
Kinase, Serine/threonine-protein kinase, Transferase |
Subcellular Location |
Cytoplasm, Cell projection > lamellipodium, Cleavage furrow, Cytoplasm > cytoskeleton |
Expression |
Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues. Accumulates in well differentiated enterocytes of the intestinal epithelium in response to tumor necrosis factor (TNF). |
Structure |
All isoforms including Telokin bind calmodulin. Interacts with SVIL. Interacts with CTTN; this interaction is reduced during thrombin-induced endothelial cell (EC) contraction but is promoted by the barrier-protective agonist sphingosine 1-phosphate (S1P) within lamellipodia. A complex made of ABL1, CTTN and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Binds to NAA10/ARD1 and PTK2B/PYK2. |
Alternative Nomenclature |
caMLCK antibody cardiac MLCK antibody Cardiac-MyBP-C-associated Ca/CaM kinase antibody MLC kinase antibody MLCK antibody MLCK2 antibody Mylk3 antibody Myosin light chain kinase 3 antibody Putative myosin light chain kinase 3 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
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MYLK-101AP | |||
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MYLK-BIOTIN | |||
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MYLK-FITC | |||
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PC-MYLK | |||
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