General Information

Product

CRMP2 Antibody

Description

Affinity Purified Collapsin response mediated protein 2 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken from within the region corresponding to AA 60-115 of the CRMP2 protein. The 26mer peptide was conserved in several other species. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero-bifunctional cross linker for immunogen preparation.

Accession #

NCBI: NP_001184222.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: Tris glycine, Tris HCl, 30% Glycerol, 0.5% BSA, HEPES

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500. Detects a band of approximately 64 kDa in PC-CRMP2 samples. In Jurkat cells, the antibody labels a smaller band (MW 54-56 kDa), the identity of this protein is not known, but may represent a splice variant or proteolysis product of CRMP2 protein.

Protein

Uniprot #

Q16555

Overview

Involved in neuronal development and polarity, axon growth and guidance,  neuronal growth cone collapse,  and cell migration.  Is needed for signalling by class 3 semaphorins and later remodeling of the cytoskeleton.

Molecular Function

Dihydropyrimidinase activity; developmental protein

Subcellular Location

Cytoplasm; Cytoskeleton; Membrane

Expression

Ubiquitous

Structure

Homotetramer and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5.  Intteracts via its C-terminus with the C-terminus of CYF1P1/SRA1.  Also interacts with HTR4, CLN6 and MICALL1.

Alternative Nomenclature

CRAM antibody

DHPRP 2 antibody

Dihydropyrimidinase 2 antibody

DPYL 2 antibody

Musunc 33 antibody

N2A3 antibody

TOAD 64 antibody

ULIP 2 protein antibody

Unc-33-like phosphoprotein 2 antibody

General Information

Product

IBP160 Antibody

Description

Affinity Purified Aquarius Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1250-1300 on human RNA helicase aquarius protein.

Accession #

NCBI:  NP_055506

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57-0.60 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O60306

Overview

Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP biogenesis

Molecular Function

RNA-binding

Subcellular Location

Nucleus, Spliceosome

Structure

Spliceosome C complex. Component of XAB2 complex.

Alternative Nomenclature

AQR antibody

fSAP164 antibody

functional spliceosome-associated protein 164 antibody

Intron-binding protein of 160 kDa antibody

General Information

Product

BTBD3 Antibody

Description

Affinity Purified BTBD/ POZ domain containing protein 3 isoform A Antibody

Verified Applications

ELISA, IHC, IPP, WB

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 410-460 on human BTBD3 protein.

Accession #

NCBI: NP_055777

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Y2F9

Overview

Acts as a key regulator of dendritic field orientation during development of sensory cortex. Directs dendrites toward active axon terminals.

Molecular Function

Neurogenesis

Subcellular Location

Cytoplasm; Nucleus

Structure

Contains BACK domain and BTB domain

Alternative Nomenclature

BTB/POZ domain-containing protein 3 antibody

dJ742J24.1 antibody

General Information

Product

Capricious Antibody Affinity Purified

Description

Affinity Purified Capricious, isoform A Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

D. melanogaster

Immunogen

Synthetic peptide corresponding to 400-450 on Capricious isoform A protein.

Accession #

NCBI:AAF49837

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:750

Protein

Uniprot #

Q9VU53

Overview

Invovled in axon guidance, branch fusion, opening tracheal system, synapse assembly and others.

Subcellular Location

Muscle cell projection

Structure

Contains Leucine-rich repeat

Alternative Nomenclature

BcDNA:LD07388 antibody

caps antibody

CG11282 antibody

CT31495 antibody

Dmel\CG11282 antibody

l(3)02937 antibody

l(3)rM632 antibody

General Information

Product

Eprhin Receptor B1 Antibody

Description

Affinity Purified Ephrin type-B receptor 1 isoform 1 Antibody

Verified Applications

ELISA, IHC, IP ,WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 850-900 on mouse Eph BR1 protein.

Accession #

NCBI:  NP_775623

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:750

Protein

Uniprot #

Q8CBF3

Overview

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

Molecular Function

ATP-binding, Nucleotide-binding

Subcellular Location

Cell membrane; Single-pass type I membrane protein; Early endosome membrane; Dendrite

Expression

Expressed in neural stem and progenitor cells in the dentate gyrus.

Structure

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts with EPHB6; transphosphorylates EPHB6 to form an active signaling complex. Interacts with PICK1. Interacts (through Tyr-594) with NCK1 (via SH2 domain); activates the JUN cascade to regulate cell adhesion. Then ligand-activated form interacts (through Tyr-928) with GRB7 and GRB10 (via SH2 domains). The ligand-activated form interacts (through Tyr-928) with GRB7 and GRB10 (via SH2 domain). Interacts with GRB2, SHC1 and SRC; activates the MAPK/ERK cascade to regulate cell migration. Interacts with CBL; regulates receptor degradation through ubiquitination. Interacts with ACP1.

Alternative Nomenclature

Cek 6 antibody

EK6 antibody

ELK antibody

Elkh antibody

Eph tyrosine kinase 2 antibody

EPH-like kinase 6 antibody

EPH2 antibody

EphB1 antibody

Ephrin receptor Eph B1 precursor antibody

Ephrin type B receptor 1 antibody

EPHT2 antibody

HEK 6 antibody

NET antibody

Neuronally expressed EPH related tyrosine kinase antibody

Tyrosine-protein kinase receptor EPH-2 antibody

General Information

Product

Inp2p Antibody Affinity Purified

Description

Affinity Purified Inheritance of peroxisomes protein 2 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Saccharomyces cerevisae

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on Saccharomyces cerevisiae S288c Inp2p protein.

Accession #

NCBI:  NP_013886.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q03824

Overview

Required for peroxisome inheritance. Acts as the peroxisome-specific receptor for the myosin V motor MYO2.

Molecular Function

protein anchor;Receptor

Subcellular Location

Membrane, Peroxisome

Structure

Belongs to the INP2 family.

Alternative Nomenclature

INP2 antibody INP2P antibody INPP2 antibody

General Information

Product

Themis Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 1-50 on Thymocyte-expressed molecule involved in selection protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8N1K5

Overview

Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells.

Molecular Function

Developmental protein

Subcellular Location

Cytoplasm, nucleus

Alternative Nomenclature

C6orf190 antibody

C6orf207 antibody

MGC163388 antibody

Protein THEMIS antibody

SIGNALING PHOSPHOPROTEIN SPECIFIC FOR T CELLS antibody

SPOT antibody

THEMIS antibody

Thymocyte expressed molecule involved in selection antibody

Thymocyte selection pathway associated antibody

TSEPA antibody

General Information

Product

C15orf42 Antibody Affinity Purified

Description

Affinity Purified Treslin Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human Treslin protein.

Accession #

NCBI:  NP_689472.3

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q7Z2Z1

Overview

Regulates triggering of DNA replication onto replication origins, required for transition from pre-replication complex to pre-initiation complex. Required to prevent mitotic entry after treatment with ionizing radiation.

Molecular Function

Chromatin binding

Subcellular Location

Nucleus

Alternative Nomenclature

C15orf42 antibody

chromosome 15 open reading frame 42 antibody

replication-stimulating protein antibody

SLD3 antibody

SLD3 homolog antibody

SLD3, yeast , homolog of antibody

TICRR antibody

TopBP1-interacting checkpoint and replication regulator antibody

Treslin antibody

General Information

Product

Timeless Antibody

Description

Affinity Purified Protein timeless homolog isoform 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide:

SGTPRVHRKKRFQIEDEDD

coresponding to amino acids 1178-1197 on Mouse Timeless protein.

Accession #

NCBI:  NP_035719.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.98-1.26 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9R1X4

Overview

Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock.

Molecular Function

Developmental protein, protein heterodimerization activity, protein homodimerization activity

Subcellular Location

Nucleus

Expression

Predominantly and robustly expressed in proliferative organs (spleen, thymus, intestine and testis) compared to those more differentiated such as kidney and liver (at protein level). Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis.

Structure

Homodimer or homomultimer. 

Alternative Nomenclature

Protein timeless homolog antibody

TIM antibody

timeless circadian clock 1 antibody

TIMELESS1 antibody

Tof1 homolog antibody

General Information

Product

Cytochrome P450 CYP307a1 Antibody Affinity Purified

Description

Affinity Purified Cytochrome P450 CYP307a1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Drosophila melanogaster

Immunogen

Synthetic peptide taken within amino acid region 500-600 on D. melanogaster Spook protein.

Accession #

GenBank: AAQ05973.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58-0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9VRM7

Overview

Required for correct development of the embryonic midline glial cells which are necessary for the formation of distinct segmental commissures.

Molecular Function

heme binding, iron ion binding, monooxygenase activity, oxidoreductase activity

Subcellular Location

endoplasmic reticulum membrane, peripheral membrane protein

Alternative Nomenclature

Cytochrome P450 307a1 antibody

307a1 antibody

CG10594 antibody

CYP307A1-Dm antibody

CG10594 antibody

Dmspo antibody

Spo antibody

spo spook antibody