General Information |
|
Product |
IP3 receptor Antibody FITC-Conjugated |
Description |
FITC-Conjugated Inositol 1,4,5-trisphosphate receptor type isoform 1 Antibody |
Verified Applications |
ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Bovine, Human, Monkey, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to unique amino acid sequence on human ITPR subtype 1 protein. |
Accession # |
NCBI: NP_001093422.2 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.52-0.63 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). |
Molecular Function |
Calcium channel, Ion channel, Ligand-gated ion channel, Receptor |
Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein |
Expression |
Widely expressed |
Structure |
Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channe |
Alternative Nomenclature |
5-trisphosphate receptor antibody DKFZp313N1434 antibody inositol 1 4 5 triphosphate receptor type 1 antibody Inositol 1 antibody InsP3R1 antibody IP3 antibody IP3 receptor antibody IP3R1 antibody ITPR 1 antibody SCA15 antibody SCA16 antibody SCA29 antibody Type 1 inositol 1 4 5 trisphosphate receptor antibody Type 1 inositol 1 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
ITPR1-101AP | |||
|
P-ITPR1 | |||
|
ITPR1-BIOTIN | |||
|
PC-ITPR1 | |||
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