General Information |
|
Product |
ENPP2 (Autotaxin) Peptide |
Description |
Antigenic Blocking Peptide ectonucleotide pyrophosphatase/phosphodiesterase 2 (Autotaxin) Antibody C-epitope |
Verified Applications |
Immunocompetition, Immunodepletion |
Peptide Description |
Synthetic peptide taken within amino acid region 778-818 on human Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) protein. |
Accession # |
GenBank: EAW91988 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Uniprot # |
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Overview |
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. |
Molecular Function |
alkylglycerophosphoethanolamine phosphodiesterase activity; calcium ion binding; hydrolase activity; lysophospholipase activity; nucleic acid binding; nucleotide diphosphatase activity; phosphodiesterase I activity; polysaccharide binding; scavenger receptor activity; transcription factor binding; zinc ion binding |
Subcellular Location |
Secreted |
Expression |
Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues. |
Structure |
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. Contains 2 SMB (somatomedin-B) domains. |
Alternative Nomenclature |
ATX antibody ATX X antibody Autotaxin antibody Autotaxin t antibody Ectonucleotide pyrophosphatase/phosphodiesterase 2 antibody Enpp2 antibody Extracellular lysophospholipase D antibody FLJ26803 antibody LysoPLD antibody NPP2 antibody PD IALPHA antibody PDNP2 antibody Phosphodiesterase I alpha antibody Plasma lysophospholipase D antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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ATX-101AP | |||
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ATX-FITC | |||
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ATX-BIOTIN | |||
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PC-ATX | |||
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