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General Information
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Product
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MAPK11 Antibody
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Description
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Affinity Purified Mitogen-activated protein kinase 11 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Chicken
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 300-350 on human Mitogen-activated protein kinase 11.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgY
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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| Immunohistochemistry |
1:50-1:100 |
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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Q15759
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Overview
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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets.
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase
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Subcellular Location
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Cytoplasm, Nucleus
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Expression
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Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
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Structure
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Interacts with HDAC3 and DUSP16.
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Alternative Nomenclature
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Human p38Beta MAP kinase mRNA complete cds antibody
MAP kinase 11 antibody
MAP kinase p38 beta antibody
Mitogen activated protein kinase 11 antibody
Mitogen activated protein kinase p38 2 antibody
Mitogen-activated protein kinase p38 beta antibody
MK11_HUMAN antibody
p38Beta antibody
PRKM11 antibody
Protein kinase mitogen activated 11 antibody
SAPK2B antibody
Stress activated protein kinase 2b antibody
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MAPK11 Antibody BIOTIN
MAPK11 Antibody FITC
MAPK11 Blocking Peptide
MAPK11 Positive Control
