DYRK2 Blocking Peptide

General Information

Product

DYRK2 Peptide

Description

Antigenic Blocking Peptide Dual specificity tyrosine-phosphorylation-regulated kinase 2 

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 550-601 on human Dual specificity tyrosine-phosphorylation-regulated kinase 2.

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q92630

Overview

Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Subcellular Location

Cytoplasm, Nucleus

Expression

Testis, after the onset of spermatogenesis.

Structure

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

Contains 1 protein kinase domain.

Alternative Nomenclature

AOMS3 antibody
Dual specificity tyrosine (Y) phosphorylation regulated kinase 1B antibody
DYR1A antibody
DYR1B antibody
Minibrain-related kinase antibody
MIRK antibody
Mirk protein kinase antibody