Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.
Molecular Function
Isomerase, Topoisomerase, ATP binding
Subcellular Location
Cytoplasm, Nucleus
Structure
Homodimer. Interacts with COPS5. Interacts with RECQL5; this stimulates DNA decatenation. Interacts with SETMAR; stimulates the topoisomerase activity.
Alternative Nomenclature
alpha isozyme antibody
ATP hydrolyzing DNA topoisomerase II alfa antibody