General Information |
|
Product |
PDE4D4 Peptide |
Description |
Antigenic Blocking Peptide cAMP-specific phoshodiesterase HPDE4D3 variant C-epitope |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic Peptide |
Accession # |
GenBank: EAW74861.1 |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
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|
|
Uniprot # |
|
Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Apical cell membrane, Cytoplasm, Membrane |
Expression |
Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. |
Structure |
Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). |
Alternative Nomenclature |
cAMP specific 3',5' cyclic phosphodiesterase 4D antibody DKFZp686M11213 antibody 5''-cyclic phosphodiesterase 4D antibody cAMP specific 3' 5' cyclic phosphodiesterase 4D antibody cAMP specific phosphodiesterase PDE4D6 antibody DPDE3 antibody Dunce like phosphodiesterase E3 antibody FLJ97311 antibody HSPDE4D antibody PDE 43 antibody Pde4d antibody Drosophila antibody STRK 1 antibody |
Protein information supplied by UniProt
Fabgennix PDE4D4 Antibody has been used in 3 Publications |
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Wang, Zhen-Zhen, et al. "Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice." Scientific Reports 5 (2015). PMID26161529
|
Western Blot; Mouse |
Li, Yun-Feng et al. “Phosphodiesterase-4D Knockout and RNAi-Mediated Knockdown Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling.” The Journal of neuroscience : the official journal of the Society for Neuroscience 31.1 (2011): 172–183. PMC3079568
|
Western Blot; Mouse |
Hajjhussein, Hassan et al. “Changes in NMDA Receptor-Induced Cyclic Nucleotide Synthesis Regulate the Age-Dependent Increase in PDE4A Expression in Primary Cortical Cultures.” Brain research 1149 (2007): 58–68. PMC2720317
|
Immunoprecipitation, Western Blot; Human |
Publishing research using PD4D4-441AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
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PD4D4-442AP | |||
|
PD4D4.c-FITC | |||
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PD4D4.c-BIOTIN | |||
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PC-PD4D4 | |||
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