General Information
|
|
Product
|
PDE7A Antibody BIOTIN-Conjugated
|
Description
|
BIOTIN-Conjugated cAMP-specific cyclic nucleotide phosphodiesterase PDE7A3 Antibody
|
Verified Applications
|
CM, ELISA, ICC, IF, IHC, IP, WB
|
Host
|
Rabbit
|
Species Cross Reactivity
|
Human, Mouse, Rat
|
Immunogen
|
Synthetic cyclic peptide common to all PDE7A variants.
|
Specificity |
This antibody is specific for PDE7A variants and will not cross-react with PDE7B or other PDE family members. |
Accession #
|
GenBank: AAK57640.1
|
Physical Properties
|
|
Quantity
|
100 µg
|
Volume
|
200 µl
|
Concentration
|
0.5 µg/µl in antibody stabilization buffer
|
Form
|
BIOTIN-Conjugated
|
Clonality
|
Polyclonal
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Confocal Microscopy
|
1:100-1:250
|
DB
|
1:10,000
|
ELISA
|
1:10,000
|
Immunocytochemistry
|
1:100-1:250
|
Immunofluorescence
|
1:100-1:250
|
Immunohistochemistry
|
1:100-1:250
|
Immunoprecipitation
|
1:250
|
Western Blot
|
1:500
|
Protein
|
Uniprot #
|
Q13946
|
Overview
|
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
|
Molecular Function
|
3', 5' -cyclic-AMP phosphodiesterase activity
|
Subcellular Location
|
Isoform PDE7A1 : Cytoplasm › cytosol, Isoform PDE7A2: Cytoplasm
|
Expression
|
PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.
|
Structure
|
Interacts with CBFA2T3
|
Alternative Nomenclature
|
HCP 1 antibody
P2A antibody
PDE 7 antibody
PDE 7A antibody
PDE1/PDE2 yeast human complement of antibody
Phosphodiesterase 7A antibody
Phosphodiesterase isozyme 7 antibody
Rolipram insensitive phosphodiesterase type 7 antibody
TM22 antibody
|
|
|