General Information
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Product
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Pan PDE9A Antibody FITC-Conjugated
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Description
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FITC-Conjugated High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a Antibody
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Verified Applications
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ELISA, ICC/IF, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic cyclic peptide common to all PDE9A variants
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Specificity |
This antibody does not cross-react with PDE9B protein or any other PDE family members. |
Accession #
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NCBI: NP_002597.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.55 µg/µl in antibody stabilization buffer
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Form
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FITC-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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Confocal Microscopy
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1:100
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DB
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1:100
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ELISA
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1:100
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Immunocytochemistry
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1:100
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Immunofluorescence
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1:100
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Immunohistochemistry
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1:100
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Immunoprecipitation
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1:250
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Western Blot
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1:500
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Protein
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Uniprot #
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O76083
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Overview
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Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
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Molecular Function
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Hydrolase, 3', 5' -cyclic-GMP phosphodiesterase activity
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Subcellular Location
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Isoform PDE9A1: Cell projection, Cytoplasm, Golgi Apparatus, Endoplasmic reticulum, Isoform PDE9A2: Cell projection, Cytoplasm, Isoform PDE9A3: Cytoplasm, Endoplasmic Reticulum, Isoform PDE9A17: Cytoplasm, Endoplasmic reticulum
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Expression
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Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate.
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Alternative Nomenclature
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FLJ90181 antibody
HSPDE9A2 antibody
PDE 9A antibody
Pde9a antibody
Phosphodiesterase 9A antibody
phosphodiesterase PDE9A21 antibody
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