Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.
Molecular Function
Lyase, Receptor
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane
Structure
Homotrimer. Interacts via its C-terminal region with PDZK2. Interacts with the lectin chaperone VIP36
Alternative Nomenclature
ANP C antibody
ANPRC antibody
Atrial natriuretic peptide C type receptor antibody
Atrionatriuretic peptide receptor C antibody
C5orf23 antibody
FLJ14054 antibody
GUCY2B antibody
MGC22189 antibody
Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) antibody
Fabgennix PGCCAntibody has been used in 3 Publications
Han, Xiaonan et al. “Loss of Guanylyl Cyclase C (GCC) Signaling Leads to Dysfunctional Intestinal Barrier.” Ed. Guillaume Dalmasso.PLoS ONE6.1 (2011): e16139.PMC3031533
Confocal Microscopy; Immunofluorescence; Immunohistochemistry; Western Blot; Mouse
Garin-Laflam, M. P. et al. “Activation of GuanylateCyclase C Signaling Pathway Protects Intestinal Epithelial Cells from Acute Radiation-Induced Apoptosis.”American Journal of Physiology - Gastrointestinal and Liver Physiology296.4 (2009): G740–G749.PMC2670662
Western Blot; Mouse
Liu, Cambrian Y., Scott E. Fraser, and David S. Koos. "Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway." Journal of Comparative Neurology 516.1 (2009): 36-48.PMID19565523
Immunofluorescence, Western Blot; Mouse
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