General Information
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Product
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Apelin Antibody BIOTIN
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Rat
Predicted: Mouse
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Immunogen
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Synthetic peptide taken within amino acid region 25-77 on human Apelin protein.
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Accession #
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NCBI: NP_059109
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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BIOTIN-Conjugated
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunohistochemistry |
1:50-1:150 |
Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q9ULZ1
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Overview
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Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.
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Molecular Function
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G-protein coupled receptor binding, receptor binding
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Subcellular Location
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Secreted
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Expression
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Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.
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Structure
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Belongs to the apelin family.
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Alternative Nomenclature
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AGTRL1 ligand antibody
APEL antibody
Apelin-13 antibody
APJ endogenous ligand antibody
Apln antibody
XNPEP2 antibody
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