General Information
|
|
Product
|
TSG101 Positive Control
|
Description
|
Western Blot Positive Control Tumor susceptibility gene 101 protein Antibody
|
Verified Applications
|
WB
|
Immunogen
|
Purified protein.
|
Physical Properties
|
|
Quantity
|
5 Applications
|
Volume
|
Inquire
|
Form
|
Western Blot Positive Control
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Western Blot
|
1:500
|
Protein
|
Uniprot #
|
Q99816
|
Overview
|
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
|
Molecular Function
|
calcium-dependent protein binding
DNA binding
ligand-dependent nuclear receptor transcription coactivator activity
protein homodimerization activity
transcription corepressor activity
ubiquitin binding
ubiquitin protein ligase binding
virion binding
|
Subcellular Location
|
Cytoplasm
Membrane; Peripheral membrane protein
Nucleus
Late endosome membrane; Peripheral membrane protein
|
Expression
|
Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
|
Alternative Nomenclature
|
ESCRT I complex subunit TSG101 antibody
TS101_HUMAN antibody
TSG 10 antibody
TSG 101 antibody
Tumor susceptibility gene 10 antibody
Tumor susceptibility gene 101 antibody
Tumor susceptibility protein antibody
Tumor susceptibility protein isoform 3 antibody
VPS23 antibody
|
|
|