General Information
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Product
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PACAP Antibody FITC
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Description
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FITC-Conjugated Pituitary adenylate cyclase-activating polypeptide Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 125-176 on human Pituitary adenylate cyclase-activating polypeptide protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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FITC-Conjugated
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunohistochemistry |
1:50-1:250 |
Immunoprecipitation
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1:200
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Western Blot
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1:2,500-1:5,000
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Protein
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Uniprot #
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P18509
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Overview
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Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells.
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Molecular Function
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neuropeptide hormone activity
peptide hormone receptor binding
pituitary adenylate cyclase activating polypeptide activity
pituitary adenylate cyclase-activating polypeptide receptor binding
receptor binding
signal transducer activity, downstream of receptor
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Subcellular Location
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Secreted
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Expression
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Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
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Structure
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Belongs to the glucagon family.
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Alternative Nomenclature
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adenylate cyclase activating polypeptide 1 (pituitary) antibody
PACAP antibody
PACAP-related peptide antibody
Pituitary adenylate cyclase-activating polypeptide 27 antibody
Pituitary adenylate cyclase-activating polypeptide 38 antibody
Pituitary adenylate cyclase-activating polypeptide antibody
prepro-PACAP antibody
PRP-48 antibody
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