General Information
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Product
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TRPV6 Antibody BIOTIN-Conjugated
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Description
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BIOTIN-Conjugated Transient receptor potential cation channel, subfamily V, member 6 Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken from the region within amino acids 700-732 of TRPV6 protein. The peptide was covalently modified to acheive desired antigenicity. Modified peptide was covalently coupled to a carrier protein by heterobifunctional cross linker for immunogen preparation.
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Accession #
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GenBank: EAW51899.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.67 µg/µl in antibody stabilization buffer
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Form
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BIOTIN-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Western Blot
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1:500
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Protein
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Uniprot #
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UPI00000380EC
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Overview
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Calcium selective cation channel probably involved in Ca2+ uptake in various tissues, including Ca2+ reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca2+-dependent and a slower Ca2+-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg2+ in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
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Molecular Function
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Calcium channel activity; Calmodulin binding
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Subcellular Location
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Cell membrane; Multi-pass membrane protein
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Expression
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Abundantly expressed in pancreas and placenta, and to a much lesser extend in stomach and kidney. Not detected in intestine.
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Structure
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Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmo
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Alternative Nomenclature
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ABPZF antibody
Alu binding protein with zinc finger domain antibody
Calcium channel CaT1 antibody
Calcium transport protein 1 antibody
CaT L antibody
CaT1 antibody
ecac antibody
ECaC2 antibody
Epithelial apical membrane calcium transporter/channel CaT1 antibody
Epithelial calcium channel 2 antibody
HSA277909 antibody
LP6728 antibody
NUDC antibody
Transient receptor potential cation channel subfamily V member 6 antibody
TrpV6 antibody
ZFAB antibody
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