General Information |
|
Product |
Pan PDE3B Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated cGMP-inhibited 3',5'-cyclic phosphodiesterase B Antibody |
Verified Applications |
CM, ELISA, ICC, IHC, IP, WB |
Host |
Goat |
Species Cross Reactivity |
Chicken, Human, Monkey, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1060-1110 on human PDE3B protein. |
Specificity | This antibody does not cross react with PDE4A variants nor with any other PDE famly members. This antibody will recognize PDE3B variants. |
Accession # |
Gen Bank: BAA09306 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.55 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Confocal Microscopy |
1:500 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:500 |
Immunofluorescence |
1:500 |
Immunohistochemistry |
1:500 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Membrane; Multipass membrane protein |
Expression |
Abundant in adipose tissues. |
Structure |
Interacts with PIK3CG. Interacts with RAPGEF3 and PIK3R6 (By similarity). |
Alternative Nomenclature |
5''-cyclic phosphodiesterase B antibody adipocyte cAMP phosphodiesterase cGMP inhibited antibody AI847709 antibody cAMP Phosphodiesterase, adipocyte, cGMP-inhibited antibody CGIP1 antibody CGIPDE B antibody cGMP inhibited 3 5 cyclic phosphodiesterase B antibody CGMP inhibited cAMP phophodiesterase antibody cGMP-inhibited 3'' antibody Cyclic GMP-inhibited phosphodiesterase B antibody Cyclic nucleotide phosphodiesterase antibody HcGIP1 antibody Phosphodiesterase 3B cGMP inhibited antibody |
Protein information supplied by UniProt
Fabgennix Goat PDE3B Antibody has been used in 3 Publications |
|
Huang, Lei, et al. "Phosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain Injury." The Journal of Neuroscience 35.29 (2015): 10390-10401. PMC4510283
|
Western Blot; Rat |
Sahu, Maitrayee, and Abhiram Sahu. "Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus." Peptides 73 (2015): 35-42. PMID26297880
|
Confocal Microscopy, Immunocytochemistry, Immunohistochemistry; Mouse |
Sahu, Maitrayee, David G. Litvin, and Abhiram Sahu. “Phosphodiesterase-3B Is Expressed in Proopiomelanocortin and Neuropeptide Y Neurons in the Mouse Hypothalamus.” Neuroscience letters 505.2 (2011): 93–97.
|
Immunocytochemistry, Western Blot; Mouse |
Publishing research using PD3B-112AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PD3B.112 | |||
|
PD3B-112AP | |||
|
PD3B.112-FITC | |||
|
PC-PD3B | |||
Display accessory details |
Select your currency:
(c) FabGennix International Inc.