General Information
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Product
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BACE2 B Antibody BIOTIN-Conjugated
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Description
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BIOTIN-Conjugated beta-secretase 2 isoform B preproprotein Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Monkey
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Immunogen
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Synthetic peptide taken within amino acid region 350-396 on human BACE2B protein.
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Specificity |
This antibody will only detect BACE2B. This antibody will not cross react with BACE2A or BACE2B. |
Accession #
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NCBI: NP_620477
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.55-0.59 µg/µl in antibody stabilization buffer
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Form
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BIOTIN-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunoprecipitation |
1:200 |
Western Blot
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1:500
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Protein
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Uniprot #
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Q9Y5Z0
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Overview
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Responsible for the proteolytic processing of the amyloid precursor protein. Cleaves APP between 690 and 691 leading to the generation and extracellular release of beta-cleaved soluble APP and C-terminal fragment which is later released by gamma-secretase.
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Molecular Function
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Aspartic-type endopeptidase activity.
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Subcellular Location
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Endoplasmic reticulum, Endosome, Golgi apparatus; Membrane
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Expression
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Neurons within the hippocampus, frontal cortex and temporal cortex. Lower expression in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Also found in spinal cord, medulla oblongata, substania nigra and locus coruleus. Expressed in ductal epithelium of prostate.
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Structure
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Belongs to the peptidase A1 family.
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Alternative Nomenclature
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ALP 56 antibody
ASP1 antibody
ASP21 antibody
Aspartic Like Protease 56kDa antibody
Downs Syndrome Region Aspartic Protease antibody
DRAP antibody
Memapsin-1 antibody
Membrane associated aspartic protease 1 antibody
Theta-secretase antibody
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