General Information |
|
Product |
ErbB 2 Peptide |
Description |
Antigenic Blocking Peptide Receptor tyrosine-protein kinase erB-2 isoform A C-epitope |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 1205-1255 receptor tyrosine-protein kinase erbB-2 protein. |
Accession # |
NCBI: NP_004439.2 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
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|
Competition/Depletion assay |
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Uniprot # |
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Overview |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). |
Molecular Function |
Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus. |
Expression |
Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. |
Structure |
Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG). |
Alternative Nomenclature |
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody CD340 antibody CerbB2 antibody cneu antibody Erb B2 antibody erbb2 antibody Erythroblastosis Virus antibody HER 2 antibody Herstatin antibody Metastatic lymph node gene 19 protein antibody MLN 19 antibody NEU antibody Neuro Glioblastoma Derived Oncogene Homolog antibody NGL antibody p185 ErbB2 antibody Proto-oncogene Neu antibody Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody Tyrosine kinase-type cell surface receptor HER2 antibody V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
ERB2-212AP | |||
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ERB2-212-BIOTIN | |||
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ERB2-212-FITC | |||
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PC-HER2 | |||
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