General Information |
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Product |
CD300 Positive Control |
Description |
Western Blot Positive Control CMRF35-like molecule 1 / CD300LF Antibody |
Verified Applications |
WB |
Immunogen |
Purified protein. |
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|
Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement. |
Molecular Function |
ceramide binding interleukin-4 receptor binding phosphatidylserine binding |
Subcellular Location |
Cell membrane; Single-pass type I membrane protein |
Expression |
Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells. |
Alternative Nomenclature |
CD300 antigen like family member antibody CD300 antigen-like family member F antibody CD300f antibody CD300LF antibody CLM antibody CLM-1 antibody CMRF35-like molecule 1 antibody IGSF antibody IgSF13 antibody Immune receptor expressed on myeloid cells 1 antibody immunoglobin superfamily member antibody Immunoglobulin superfamily member 13 antibody Inhibitory receptor IREM1 antibody IREM antibody IREM-1 antibody Nepmucin antibody NK inhibitory receptor antibody NKIR antibody TREM antibody triggering receptors expressed on myeloid cells antibody UNQ3105/PRO10111 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
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CD300LF-101AP | |||
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CD300LF-BIOTIN | |||
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CD300LF-FITC | |||
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P-CD300LF | |||
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