General Information
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Product
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S100 beta Antibody Affinity Purified
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Description
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Affinity Purified Protein S100-P Antibody C-epitope
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Rat
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Immunogen
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C-epitope synthetic peptide corresponding to unique amino acid sequences on human S100 protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.65 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Determinant
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C-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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Confocal Microscopy
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DB
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1:10,000
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ELISA
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1:10,000
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Western Blot
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1:500
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Protein
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Uniprot #
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P25815
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Overview
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May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
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Molecular Function
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Calcium-dependent protein binding, calcium ion binding, magnesium ion binding
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Subcellular Location
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Nucleus, cytoplasm, Cell projection > microvillus membrane
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Expression
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Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial n
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Structure
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Homodimer and heterodimer with S100A1. Interacts with S100PBP and S100Z. Interacts with CACYBP in a calcium-dependent manner. Dimeric form binds to and activates EZR/Ezrin by unmasking its F-actin binding sites. Interacts with PPP5C (via TPR repeats); the
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Alternative Nomenclature
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NEF antibody
S 100 calcium binding protein beta chain antibody
S 100 protein beta chain antibody
S 100 protein beta subunit antibody
S100 calcium-binding protein B antibody
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