General Information |
|
Product |
DWORF Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Mouse |
Immunogen |
Synthetic peptide taken within amino acid region 1-30 on mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunohistochemistry |
1:100 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulates SERCA pump activity. Enhances sarcoplasmic reticulum Ca2+ uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN). |
Subcellular Location |
Sarcoplasmic reticulum membrane; Single-pass membrane protein |
Expression |
Highly expressed in heart (at protein level). Detected in heart and soleus, a postural muscle group of the hindlimb containing the highest enrichment of slow-twitch muscle fibers. Also expressed in diaphragm, which contains some slow-twitch fibers. Not detected in the quadriceps, a fast-twitch muscle group, or in cardiac atrial muscle. Not expressed in the prenatal heart but gradually increases in abundance postnatally. |
Alternative Nomenclature |
Dwarf open reading frame antibody DWORF antibody Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF SERCA regulator DWORF antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
DWORF-101AP | |||
|
DWORF-FITC | |||
|
P-DWORF | |||
|
PC-DWORF | |||
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