General Information |
|
Product |
PREX1 Antibody FITC-Conjugated |
Description |
FITC-Conjugated Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Monkey, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified.
Sequence: QEEDQADSAFPLLSLGPRLSLC |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.6 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:20,000-1:50,000 |
ELISA |
1:20,000-1:50,000 |
Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation | 1:200 |
Western Blot |
1:500-1:750 |
|
|
Uniprot # |
|
Overview |
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
Molecular Function |
enzyme binding, Rho GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, phospholipid binding |
Subcellular Location |
Cytoplasm, cell membrane |
Expression |
Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. |
Alternative Nomenclature |
4 antibody 5)-dependent Rac exchanger 1 antibody P REX1 antibody PtdIns(3,4,5) dependent Rac exchanger 1 antibody SET domain containing 6 antibody Setd6 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
PREX-101AP | |||
|
P-PREX | |||
|
PREX-BIOTIN | |||
|
PC-PREX1 | |||
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