General Information
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Product
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UFD1L Peptide
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Description
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Antigenic Blocking Peptide UFD1L Purified 20 kDa UFD1L protein Antibody
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic Peptide
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Accession #
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GenBank: CAG30493.1
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q92890
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Overview
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Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
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Molecular Function
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Ubiquitin-specific protease activity
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Subcellular Location
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Nucleus; Cytosol
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Expression
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Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.
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Structure
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Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13.
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Alternative Nomenclature
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UB fusion protein 1 antibody
Ubiquitin fusion degradation 1 like (yeast) antibody
Ubiquitin fusion degradation protein 1 homolog antibody
UFD1 antibody
UFD1L antibody
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