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PDE1A Antibody

Product no.: PD1A-101AP

Description
Publications

General Information
Product	PDE1A Antibody
Description	Affinity Purified Phosphodiesterase 1A Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence within amino acid region 1-50 on PDE1A protein. Common to all PDE1A variants.
Specificity	This antibody will not label other PDE family members. This antibody will label all PDE1 variants including PDE1A1, PDE1A3, PDE1A5.
Accession #	NCBI: NP001009978.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.59 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:500-1:1,000
Protein
Uniprot #	Q9JLL9
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Molecular Function	Hydrolase, calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity, metal ion binding
Subcellular Location	Cytosol
Expression	Several tissues, including brain, kidney, testes and heart.
Structure	Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Alternative Nomenclature	3' 5' cyclic nucleotide phosphodiesterase antibody 61 kDa Cam PDE antibody Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A antibody Calcium/calmodulin-dependent 3'' antibody Calmodulin-dependent Phosphodiesterase antibody Cam PDE 1A antibody HSPDE1A antibody MGC26303 antibody PDE1A antibody Phosphodiesterase 1A antibody Phosphodiesterase 1A calmodulin dependent antibody

Protein information supplied by UniProt

Fabgennix PDE1A Antibody has been used in 16 Publications
Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015). PMID25704994	Immunohistochemistry, Western Blot; Human
Rajagopal, Senthilkumar, et al. "Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation." Journal of Pharmacology and Experimental Therapeutics 352.3 (2015): 509-518. PMID25550199	Western Blot; Mouse
Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014): 916-926. PMID24631654	Immunohistochemistry, Western Blot; Mouse
Ückert, Stefan, et al. "Phosphodiesterase type 1, calcitonin gene-related peptide and vasoactive intestinal polypeptide are involved in the control of Human vaginal arterial vessels." European Journal of Obstetrics & Gynecology and Reproductive Biology 169.2 (2013): 283-286. PMID23490535	Immunohistochemistry; Human
Abusnina, Abdurazzag, et al. "Anti‐prolifeRative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integRator UHRF1." Molecular nutrition & food research 55.11 (2011): 1677-1689. PMID22045655	Western Blot; Human
Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011): E342-E350. PMID21653225	Immunofluorescence, Western Blot; Human
Abusnina, Abdurazzag, et al. "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." Cellular signalling 23.1 (2011): 152-160. PMID20807569	Western Blot; Human
Tahseldar-Roumieh, Rima et al. “PDEs1-5 Activity and Expression in Tissues of Cirrhotic Rats Reveal a Role for Aortic PDE3 in NO Desensitization.” International Journal of Experimental Pathology 90.6 (2009): 605–614. PMC2803251	Western Blot; Rat
Ortiz-Capisano, M. Cecilia et al. “Calcium-Dependent Phosphodiesterase 1C Inhibits Renin Release from Isolated Juxtaglomerular Cells.” American Journal of Physiology - Regulatory, Integrative and Comparative Physiology297.5 (2009): R1469–R1476. PMID19741056	Immunoprecipitation; Mouse
Deplano, Stefania, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase during ontogenesis of chick retina." Journal of neuroscience research 86.5 (2008): 1017-1023.PMID18041092	Immunohistochemistry, Western Blot; Chicken
Albrecht, Knut, et al. "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the Human vagina: A potential forensic value?." Journal of forensic and legal medicine 14.5 (2007): 270-274. PMID17113813	Immunohistochemistry; Human
Murray, Fiona, et al. "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." American Journal of Physiology-Lung Cellular and Molecular Physiology 292.1 (2007): L294-L303.PMID16980375	Western Blot; Human
Santone, Rocco, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase in adult Rat retina." Journal of neuroscience research 84.5 (2006): 1020-1026. PMID16881052	Confocal Microscopy, Immunohistochemistry; Rat
SAIRENJI, Nakayasu, Keitaro SATOH, and Hiroshi SUGIYA. "Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase in cGMP metabolism in Rabbit parotid acinar cells." Biomedical Research 27.1 (2006): 37-44. PMID16543664	Western Blot; Rabbit
Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005): 495-508. PMID15856425	Immunofluorescence, Western Blot; Mouse
Whitehead, Clark M., et al. "Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival." Molecular cancer therapeutics 2.5 (2003): 479-488. PMID12748310	Immunohistochemistry; Human

Publishing research using PD1A-101AP? Please let us know, we can cite the reference in this datasheet.

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PDE1A Antibody FITC

PD1A-FITC

PDE1A Antibody BIOTIN

PD1A-BIOTIN

PDE1A Blocking Peptide

P-PD1A

PDE1A Positive Control

PC-PD1A

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PDE1A7 Antibody

C-epitope

PDE1A Antibody

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PDE1B Antibody

Product no.: PD1B-201AP

Description
Publications

General Information
Product	PDE1B Antibody
Description	Affinity Purified Pan Phosphodiesterase 1B Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on PDE1B gene.
Specificity	This antibody does not cross-react with PDE1A or PDE1C or any known PDE family m ember. This antibody will label all PDE1B variants.
Accession #	GenBank: EDL03912.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.58 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:50-1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:50-1:200
Immunofluorescence	1:50-1:200
Immunohistochemistry	1:50-1:200
Immunoprecipitation	1:200
Western Blot	1:500-1:1,000. Predicted molecular weight: 65 kDa. This antibody labels multiple bands in the 65-72 kDa range all believed to be various PDE1B variants.
Protein
Uniprot #	UPI000154A3CC
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Molecular Function	Calmodulin-binding, cAMP, cGMP, Metal-binding
Subcellular Location	Cytoplasm
Structure	Homodimer
Alternative Nomenclature	5''-cyclic nucleotide phosphodiesterase 1B antibody 63 kDa Cam PDE antibody Calcium/calmodulin dependent 3' 5' cyclic nucleotide Phosphodiesterase 1B antibody PDE1B1 antibody Cam PDE 1B antibody PDE1B antibody PDE1B1 antibody PDES 1B antibody Phosphodiesterase 1B antibody Phosphodiesterase 1B calmodulin dependent antibody

Protein information supplied by UniProt

Fabgennix PDE1B Antibody has been used in 10 Publications

Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602

Immunohistochemistry; Human

Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014): 916-926. PMID24631654

Immunohistochemistry, Western Blot; Mouse

Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011): E342-E350.

PMID21653225

Immunofluorescence, Western Blot; Rat

Abusnina, Abdurazzag, et al. "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." Cellular signalling 23.1 (2011): 152-160. PMID20807569

Western Blot; Human

Abusnina, Abdurazzag, et al. "Anti‐prolifeRative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integRator UHRF1." Molecular nutrition & food research 55.11 (2011): 1677-1689. PMID22045655

Western Blot; Human

Dong, Hongli, et al. "Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells." Biochemical pharmacology 79.3 (2010): 321-329. PMID19737543

Western Blot; Human

Tahseldar-Roumieh, Rima et al. “PDEs1-5 Activity and Expression in Tissues of Cirrhotic Rats Reveal a Role for Aortic PDE3 in NO Desensitization.” International Journal of Experimental Pathology 90.6 (2009): 605–614. PMC2803251

Western Blot; Rat

Ortiz-Capisano, M. Cecilia et al. “Calcium-Dependent Phosphodiesterase 1C Inhibits Renin Release from Isolated Juxtaglomerular Cells.” American Journal of Physiology - Regulatory, Integrative and Comparative Physiology297.5 (2009): R1469–R1476. PMC2853420

Western Blot; Mouse

Dlaboga, Daniel, Hassan Hajjhussein, and James M. O'Donnell. "Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B,-4B, and-10A expression in Rat striatum." Neuropharmacology 54.4 (2008): 745-754. PMID18222493

Western Blot; Rat

Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005): 495-508. PMID15856425

Immunofluorescence, Western Blot; Mouse

Publishing research using PD1B-201AP? Please let us know, we can cite the reference in this datasheet.

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PDE1B Antibody FITC

PD1B-FITC

PDE1B Antibody BIOTIN

PD1B-BIOTIN

PDE1B Blocking Peptide

P-PD1B

PDE1B Positive Control

PC-PD1B

Display accessory details

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PDE1C Antibody

Product no.: PD1C-301AP

General Information
Product	PDE1C Antibody
Description	Affinity Purified Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A) Antibody N-epitope
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene. The sequence was taken within amino acid region 1-50.
Specificity	This antibody does not cross-react with PDE1A, PDE1B, or other PDE family members. This antibody will label all PDE1C variants including PDE1C1, PDE1C2, and PDE1C3.
Accession #	GenBank: U40371.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	N-epitope
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:40-1:100
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:40-1:100
Immunofluorescence	1:100
Immunohistochemistry	1:40-1:100
Immunoprecipitation	1:200
Western Blot	1:500-1:2,000
Protein
Uniprot #	Q14123
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.
Molecular Function	Hydrolase, calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, metal ion binding
Subcellular Location	Cytosol
Expression	Expressed in several tissues, including brain and heart.
Structure	Homodimer
Alternative Nomenclature	5''-cyclic nucleotide phosphodiesterase 1C Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C Cam PDE 1C HCAM3 HSPDE1C1A Human 3'5' cyclic nucleotide Phosphodiesterase PDE 1C Phosphodiesterase 1C Phosphodiesterase 1C calmodulin dependent

Protein information supplied by UniProt

FabGennix PDE1C Antibody has been used in 16 Publications

Applications: Confocal microscopy, Immunodepletion, Immunofluorescence, Immunohistochemistry, and Western blot

Reactivity: Chicken, Human, Mouse, and Rat

Cesarini, Valeriana, et al. "Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome." Oncotarget (2017).

PMID: 28099939

Applications: Western Blot

Reactivity: Human

Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015).

PMID: 25578602

Applications: Immunohistochemistry

Reactivity: Human

PMID: 24631654

Applications: Immunohistochemistry, Western Blot

Reactivity: Mouse

Guibinga, Ghiabe-Henri, Fiona Murray, and Nikki Barron. “HPRT-Deficiency Dysregulates cAMP-PKA Signaling and Phosphodiesterase 10A Expression: Mechanistic Insight and Potential Target for Lesch-Nyhan Disease?” Ed. Kjetil Tasken. PLoS ONE 8.5 (2013).

PMCID: 3653951

Applications: Western Blot

Reactivity: Human

PMID: 21653225

Applications: Immunofluorescence, Western Blot

Reactivity: Mouse

PMID: 20807569

Applications: Western Blot

Reactivity: Human

Abusnina, Abdurazzag, et al. "Anti‐proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1." Molecular nutrition & food research 55.11 (2011).

PMID: 22045655

Applications: Western Blot

Reactivity: Human

PMID: 19737543

Applications: Western Blot

Reactivity: Human

PMCID: 2777770

Applications: Confocal microscopy, Immunohistochemistry, Immunofluorescence, Western Blot

Reactivity: Mouse

PMCID: 2803251

Applications: Western Blot

Reactivity: Rat

Deplano, Stefania, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase during ontogenesis of chick retina." Journal of neuroscience research 86.5 (2008).

PMID: 18041092

Applications: Immunohistochemistry, Western Blot

Reactivity: Chicken

Dunkern, Torsten R., and Armin Hatzelmann. "Characterization Of Inhibitors Of Phosphodiesterase 1C On A Human Cellular System." FEBS Journal 274.18 (2007).

PMID: 17697115

Applications: Western Blot

Reactivity: Human

Murray, Fiona, et al. "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." American Journal of Physiology-Lung Cellular and Molecular Physiology 292.1 (2007).

PMID: 16980375

Applications: Western Blot

Reactivity: Human

Santone, Rocco, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase in adult Rat retina." Journal of neuroscience research 84.5 (2006).

PMID: 16881052

Applications: Confocal microscopy, Immunohistochemistry, Western Blot

Reactivity: Rat

Dolci, Susanna, et al. "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases." Biochemical and biophysical research communications 341.3 (2006).

PMID: 16455054

Applications: Immunodepletion, Immunofluorescence, Western Blot

Reactivity: Human

PMID: 15856425

Applications: Immunofluorescence, Western Blot

Reactivity: Mouse

Publishing research using PD1C-301AP? Please let us know, we can cite the reference in this datasheet.

On your PDE1c western blot data sheet there are multiple bands from different tissue origin lysates. As we are having problems with the size of PDE1c, can you tell us or mark these sizes of the PDE1C splice variants?

The PDE1C splice variants are described in detail in Yan C et al. The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner. J Biol Chem 271:25699-706 (1996). Please refer to this reference as it is useful in describing th

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PDE1C Antibody FITC

PD1C-FITC

PDE1C Antibody BIOTIN

PD1C-BIOTIN

PDE1C Blocking Peptide

P-PD1C

PDE1C Positive Control

PC-PD1C

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PDE1C Antibody

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PDE1C Antibody

Product no.: PD1C-312AP

Description
Q&A

General Information
Product	PDE1C Antibody
Description	Affinity Purified Pan Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A) Antibody C-epitope
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene. The sequence was taken within amino acid region 10-70.
Specificity	This antibody does not cross-react with PDE1A, PDE1B, or other PDE family members. This antibody will label all PDE1C variants including PDE1C1, PDE1C2, and PDE1C3.
Accession #	GenBank: U40371.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	This antibody is labeled as C-epitope, because it was taken closer to the C-terminus in relation to our other PDE1C antibody (PD1C-301AP).
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:40-1:100
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:40-1:100
Immunofluorescence	1:200
Immunohistochemistry	1:40-1:100
Immunoprecipitation	1:200
Western Blot	1:500-1:2,000
Protein
Uniprot #	Q14123
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.
Molecular Function	Hydrolase, calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, metal ion binding
Subcellular Location	Cytosol
Expression	Expressed in several tissues, including brain and heart.
Structure	Homodimer
Alternative Nomenclature	5''-cyclic nucleotide phosphodiesterase 1C antibody Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C antibody Cam PDE 1C antibody HCAM3 antibody HSPDE1C1A antibody Human 3'5' cyclic nucleotide Phosphodiesterase antibody PDE 1C antibody Phosphodiesterase 1C antibody Phosphodiesterase 1C calmodulin dependent antibody

Protein information supplied by UniProt

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PDE1C Antibody FITC

PD1C.c-FITC

PDE1C Antibody BIOTIN

PD1C.c-BIOTIN

PDE1C Blocking Peptide

P-PD1C.c

PDE1C Positive Control

PC-PD1C

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PDE4A Antibody

Product no.: PD4A-112AP

General Information
Product	PDE4A Antibody
Description	Affinity Purified Phosphodiesterase 4A Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Moose, Mouse, Rat
Immunogen	Synthetic cyclic peptide corresponding to the C-terminal region of PDE4A. Common to all PDE4A proteins.
Specificity	This antibody labels all known PDE4A variants including PDE4A1 (66 kDa), PDE4A5 (109 kDa), PDE4A8 (106 kDa), AND PDE4Ax (10 kDa) and a 76 kDa testis specific A variant.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:100-1:400
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:100-1:400
Immunofluorescence	1:100-1:400
Immunohistochemistry	1:100-1:400
Immunoprecipitation	1:250
Western Blot	1:1,000-1:2,500
Protein
Uniprot #	P27815
Overview	Hydrolyzes the second messenger cAMP which is a key regulator of many important physiological processes.
Molecular Function	cAMP
Subcellular Location	Isoform 1: perinuclear region, Isoform 2: ruffle membrane, Isoform 4: Peripheral membrane protein, Isoform 6: perinuclear region, Isoform 7: Membrane, Cytoplasm
Expression	Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lympohocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).
Structure	Belongs to cyclic nucleotide phosphodiesterase family. PDE4 subfamily
Alternative Nomenclature	5''-cyclic phosphodiesterase 4A cAMP specific 3 5 cyclic phosphodiesterase 4A DPDE2 dunce like phosphodiesterase E2 PDE 4A PDE4 PDE46 PDE4A11 Phosphodiesterase 4A phosphodiesterase 4A cAMP specific phosphodiesterase E2 dunce homolog phosphodiesterase isozyme 4 phosphodiesterase type 4A11

Protein information supplied by UniProt

FabGennix PDE4A Antibody has been used in 47 Publications

Applications: Confocal microscopy, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunocytochemistry, Immunohistochemistry, and Western blot

Reactivity: Human, Moose, Mouse, and Rat

Avila, Diana V., et al. "Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol‐induced steatosis." The Journal of pathology 240.1 (2016).

PMID: 27287961

Applications: Western Blot

Reactivity: Rat

Massimi, Mara, et al. "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." Journal of Cellular Biochemistry (2016).

PMID: 27859531

Applications: Western Blot

Reactivity: Human

Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015).

PMID: 25704994

Applications: Immunohistochemistry, Western Blot

Reactivity: Human

Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015).

PMID: 25578602

Applications: Immunohistochemistry

Reactivity: Human

Guo, Jiejie, et al. "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." Neuroscience 263 (2014).

PMID: 24434771

Applications: Western Blot

Reactivity: Mouse

Zhai, Kui, et al. "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." Cellular signalling 26.5 (2014).

PMID: 23347325

Applications: Western Blot

Reactivity: Rat

Amanda, G. Vang, et al. "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." Biochemical Journal 456.3 (2013).

PMCID: 24007532

Applications: Western Blot

Reactivity: Mouse

Wang, Zhen-Zhen et al. “RNA Interference-Mediated Phosphodiesterase 4D Splice Variants Knock-down in the Prefrontal Cortex Produces Antidepressant-Like and Cognition-Enhancing Effects.” British Journal of Pharmacology 168.4 (2013).

PMCID: 3631387

Applications: Western Blot

Reactivity: Mouse

Yougbaré, Issaka, et al. "NCS 613 Exhibits Anti-Inflammatory Effects On Pbmcs From Lupus Patients By Inhibiting P38 MAPK And NF-Κb Signalling Pathways While Reducing Proinflammatory Cytokine Production." Canadian Journal Of Physiology & Pharmacology 91.5 (2013).

PMCID: 23656347

Applications: Immunocytochemistry, Western Blot

Reactivity: Human

Schaal, Sandra Marie et al. “The Therapeutic Profile of Rolipram, PDE Target and Mechanism of Action as a Neuroprotectant Following Spinal Cord Injury.” Ed. Valentin Ceña. PLoS ONE 7.9 (2012).

PMID: 3446989

Applications: Confocal microscopy, Immunofluorescence, Immunohistochemistry, Western Blot

Reactivity: Rat

Click Here for the complete list of all FabGennix PDE4A Antibody publications

Publishing research using PD4A-112AP? Please let us know, we can cite the reference in this datasheet.

To view the PD4A-112AP specification sheet, click the link below:

FabGennix PD4A-112AP Specification Sheet

Customer ratings for PDE4A Antibody

Number of ratings: 1
Average rating: 5

Excellent
from Verified Customer on 12/10/2020

1:500 dilution in Western blot. Excellent results in Sprague Dawley rats liver tissue.

All incoming ratings are posted by actual shop visitors / webshop customers and their content is checked by the operator by means of a visual inspection.

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Price

PDE4A Antibody FITC

PD4A-FITC

PDE4A Antibody BIOTIN

PD4A-BIOTIN

PDE4A Blocking Peptide

P-PD4A

PDE4A Positive Control

PC-PD4A

Display accessory details

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PDE4C Antibody

Product no.: PD4C-301AP

Description
Publications

General Information
Product	PDE4C Antibody
Description	Affinity Purified cAMP-specific 3',5'-cyclic phosphodiesterase 4C Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic cyclic carboxy-terminal peptide common to all PDE4C variants.
Specificity	This antibody detects 3 isoforms of PDE4C subclasses: PDE4C1, PDE4C2, and PDE4C3.
Accession #	NCBI: NP_001074.2
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.65 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:500-1:2,500
Protein
Uniprot #	Q08493
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Molecular Function	Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Subcellular Location	Cell projection > cillium
Expression	Expressed in various tissues but not in cells of the immune system.
Structure	Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.
Alternative Nomenclature	5''-cyclic phosphodiesterase 4C antibody cAMP specific 3' 5' cyclic phosphodiesterase 4C antibody cAMP-specific 3'' antibody DPDE 1 antibody MGC126222 antibody PDE 21 antibody PDE 4C antibody Pde4c antibody Phosphodiesterase 4C antibody Phosphodiesterase E1 dunce homolog antibody Phosphodiesterase type 4C antibody

Protein information supplied by UniProt

FabGennix PDE4C Antibody has been used in 15 Publications

Applications: Coimmunoprecipitation, Immunocytochemistry, Immunohistochemistry, and Western blot

Reactivity: Human, Mouse, and Rat

Cheng, Hao, et al. "siRNA‑mediated silencing of phosphodiesterase 4B expression affects the production of cytokines in endotoxin‑stimulated primary cultured microglia." Experimental and Therapeutic Medicine 12.4 (2016).

PMID: 27698721

Applications: Western Blot

Reactivity: Rat

Ji, Qing, et al. "Intrathecal injection of phosphodiesterase 4B-specific siRNA attenuates neuropathic pain in rats with L5 spinal nerve ligation." Molecular medicine reports 13.2 (2016).

PMCID: 26706904

Applications: Western Blot

Reactivity: Rat

Massimi, Mara, et al. "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." Journal of Cellular Biochemistry (2016).

PMCID: 27859531

Applications: Western Blot

Reactivity: Human

Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015).

PMID: 25578602

Applications: Immunohistochemistry

Reactivity: Human

PMID: 23656347

Applications: Immunohistochemistry, Western Blot

Reactivity: Human

Haque, Mohammed Z., Paulo S. Caceres, and Pablo A. Ortiz. “β-Adrenergic Receptor Stimulation Increases Surface NKCC2 Expression in Rat Thick Ascending Limbs in a Process Inhibited by Phosphodiesterase 4.” American Journal of Physiology - Renal Physiology 303.9 (2012).

PMCID: 3518189

Applications: Western Blot

Reactivity: Rat

Keravis, Thérèse et al. “Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4) Inhibitor.” Ed. Pierre Bobé. PLoS ONE 7.1 (2012).

PMCID: 3256138

Applications: Western Blot

Reactivity: Mouse

PMID: 20807569

Applications: Western Blot

Reactivity: Human

Yougbare, Issaka, et al. "NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on Human lung tissues." American Journal of Physiology-Lung Cellular and Molecular Physiology 301.4 (2011).

PMID: 21784969

Applications: Immunocytochemistry, Western Blot

Reactivity: Human

PMID: 2803251

Applications: Western Blot

Reactivity: Rat

Whitaker, Christopher M., and Nigel G. F. Cooper. “The Novel Distribution of Phosphodiesterase-4 Subtypes Within the Rat Retina.” Neuroscience 163.4 (2009).

PMCID: 2774823

Applications: Western Blot

Reactivity: Rat

Campos-Toimil, M et al. “Short-Term or Long-Term Treatments with a Phosphodiesterase-4 (PDE4) Inhibitor Result in Opposing Agonist-Induced Ca2+ Responses in Endothelial Cells.” British Journal of Pharmacology 154.1 (2008).

PMCID: 2438981

Applications: Western Blot

Reactivity: Human

Sachs, Benjamin D. et al. “P75 Neurotrophin Receptor Regulates Tissue Fibrosis through Inhibition of Plasminogen Activation via a PDE4/cAMP/PKA Pathway.” The Journal of Cell Biology 177.6 (2007).

PMCID: 2064370

Applications: Coimmunoprecipitation,

Western Blot

Reactivity: Mouse

PMID: 16980375

Applications: Western Blot

Reactivity: Human

Gallagher, Helen C., et al. "Valproate activates phosphodiesterase-mediated cAMP degradation: relevance to C6 glioma G1 phase progression." Neurotoxicology and teratology 26.1 (2004).

PMID: 15001216

Applications: Western Blot

Reactivity: Human

Publishing research using PD4C-301AP? Please let us know, we can cite the reference in this datasheet.

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PDE4C Antibody FITC

PD4C-FITC

PDE4C Antibody BIOTIN

PD4C-BIOTIN

PDE4C Blocking Peptide

P-PD4C

PDE4C Positive Control

PC-PD4C

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PDE4D3 Antibody

Product no.: PD4D3-431AP

Description
Publications

General Information
Product	PDE4D3 Antibody
Description	Affinity Purified cAMP-specific phoshodiesterase HPDE4D3 variant Antibody
Verified Applications	CM, ELISA, ICC/IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Chicken, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on PDE4D3 variant.
Specificity	This antibody does not cross react with PDE4D1, PDE4D2, PDE4D4, PDE4D5. Does not cross react with other PDE family members such as PDE4A, PDE4B or PDE4C.
Accession #	GenBank: EAW74861.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	Q08499
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Molecular Function	Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Subcellular Location	Apical cell membrane, Cytoplasm, Membrane
Expression	Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Structure	Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1).
Alternative Nomenclature	DPDE3 antibody hPDE4D3 antibody HSPDE4D antibody PDE43 antibody PDE4D antibody PDE4DN2 antibody Phosphodiesterase 4D antibody Phosphodiesterase 4D cAMP-specific antibody Phosphodiesterase Type 4D3 antibody STRK1 antibody

Protein information supplied by UniProt

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PDE4D3 Antibody FITC

PD4D3-FITC

PDE4D3 Antibody BIOTIN

PD4D3-BIOTIN

PDE4D3 Blocking Peptide

P-PD4D3

PDE4D3 Positive Control

PC-PD4D3

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PDE4D5 Antibody

Product no.: PD4D5-451AP

General Information
Product	PDE4D5 Antibody
Description	Affinity Purified cAMP-specific phosphodiesterase PDE4D5 Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rabbit, Rat
Immunogen	A 20 amino acid synthetic peptide taken from the N-terminus corresopnding to the PDE4D5 variant.
Specificity	A This antibody does not cross-react with other members of the PDE4D family or with other PDE4 proteins (PDE4A, PDE4B and PDE4C) or with other PDE family members.
Accession #	GenBank: AAC00069.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.65 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	Q08499
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Molecular Function	Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Subcellular Location	Apical cell membrane, Cytoplasm, Membrane
Expression	Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Structure	Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphotase 1 (PP1) (By similarity). Isoform 5, isoform N3 and isoform 12 bind GNB2L1 via their unique N-terminus. Binds ARRB2. Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner.
Alternative Nomenclature	cAMP-specific 3'5'-cyclic phosphodiesterase 4D antibody DPDE3 antibody dunce-like phosphodiesterase E3 antibody hPDE4D5 antibody PDE4D antibody PDE4DN2 antibody Phosphodiesterase 4D antibody Phosphodiesterase 4D cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3) antibody Phosphodiesterase 4D cAMP-specific antibody STRK1 antibody

Protein information supplied by UniProt

Fabgennix PDE4D5 Antibody has been used in 7 Publications

Zamarbide, Marta, et al. "Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability." Biological psychiatry 85.9 (2019). PMID30732858

Western Blot; Mouse

Wang, Zhen-Zhen, et al. "Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice." Scientific Reports 5 (2015). PMID26161529

Western Blot; Mouse

Mahavadi, Sunila, et al. "Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle." American Journal of Physiology-Cell Physiology 307.4 (2014): C402-C411. PMID24944202

Western Blot; Mouse

Li, Yun-Feng et al. “Phosphodiesterase-4D Knockout and RNAi-Mediated Knockdown Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling.” The Journal of neuroscience : the official journal of the Society for Neuroscience 31.1 (2011): 172–183. PMC3079568

Immunohistochemistry, Western Blot; Mouse

Nino, Gustavo et al. “Mechanism Regulating Proasthmatic Effects of Prolonged Homologous Β2-Adrenergic Receptor Desensitization in Airway Smooth Muscle.” American Journal of Physiology - Lung Cellular and Molecular Physiology 297.4 (2009): L746–L757. PMC2770790

Western Blot; Rabbit

Murthy, Karnam S., and Wimolpak Sriwai. "Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A." American Journal of Physiology-Gastrointestinal and Liver Physiology 294.1 (2008): G327-G335. PMID18006600

Immunoprecipitation, Western Blot; Human

Hajjhussein, Hassan et al. “Changes in NMDA Receptor-Induced Cyclic Nucleotide Synthesis Regulate the Age-Dependent Increase in PDE4A Expression in Primary Cortical Cultures.” Brain research 1149 (2007): 58–68. PMC2720317

Immunoprecipitation, Western Blot; Human

Publishing research using PD4D5-451AP? Please let us know, we can cite the reference in this datasheet.

To view the Specification Sheet for PDE4D5 Antibody, please click the link below:

PDE4D5 Antibody | FabGennix

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PDE4D5 Antibody FITC

PD4D5-FITC

PDE4D5 Antibody BIOTIN

PD4D5-BIOTIN

PDE4D5 Blocking Peptide

P-PD4D5

PDE4D5 Positive Control

PC-PD4D5

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PDE4D7 Antibody

Product no.: PD4D7-471AP

Description
Specification Sheet

General Information
Product	PDE4D7 Antibody
Description	Affinity Purified cAMP-specific phosphodiesterase PDE4D7 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Chicken, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on PDE4D7 variant.
Specificity	This antibody does not cross react with other PDE4D variants including PDE4D1, PDE4D2, PDE4D3, PDE4D4, PDE4D5. It also does not cross react with other PDE family members including PDE4A, PDE4B or PDE4C.
Accession #	GenBank: AF536978.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.2 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	Q01063
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Molecular Function	Hydrolase, 3',5'-cyclic-nucleotide phosphodiesterase activity, ATPase binding
Subcellular Location	Cytoplasm. Membrane. Cytoplasm › cytoskeleton. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Apical cell membrane
Expression	Expressed in brain (at protein level). Isoform 7 is detected in heart, brain, lung, kidney and testis.
Structure	Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Binds ARRB2. Interacts with PDE4DIP (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner.
Alternative Nomenclature	DPDE3 antibody HSPDE4D antibody PDE43 antibody PDE4D antibody Phosphodiesterase 4D antibody Phosphodiesterase 4D cAMP-specific antibody

Protein information supplied by UniProt

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PDE4D7 Antibody FITC

PD4D7-FITC

PDE4D7 Antibody BIOTIN

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P-PD4D7

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PDE4D8 Antibody

Product no.: PD4D8-481AP

Description

General Information
Product	PDE4D8 Antibody Affinity Purified
Description	Affinity Purified cAMP-specific phosphodiesterase PDE4D8 Antibody
Verified Applications	ELISA, IMM, WB
Host	Rabbit
Species Cross Reactivity	Chicken, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on PDE4D8 variant gene.
Accession #	GenBank: AAN10119.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.2 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	Q08499
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Molecular Function	Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Subcellular Location	Apical cell membrane, Cytoplasm, Membrane
Expression	Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Structure	Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protei
Alternative Nomenclature	cAMP-specific 3'5'-cyclic phosphodiesterase 4D antibody DPDE3 antibody dunce-like phosphodiesterase E3 antibody hPDE4D5 antibody PDE4D antibody PDE4DN2 antibody Phosphodiesterase 4D antibody Phosphodiesterase 4D cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3) antibody Phosphodiesterase 4D cAMP-specific antibody STRK1 antibody

Protein information supplied by UniProt

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PDE4D8 Antibody FITC

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P-PD4D8

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